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Mequitazine

Name: Mequitazine
Brand: TargetMol
SKU: T4499
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4499Cas No. 29216-28-2

Alias Virginan, Primalan, Metaplexan, LM-209

Mequitazine (Virginan) is an effective, nonsedative and long-acting histamine H1 antagonist.

Mequitazine

🥰Excellent

Purity: 99.98%

Catalog No. T4499Alias Virginan, Primalan, Metaplexan, LM-209Cas No. 29216-28-2

Mequitazine (Virginan) is an effective, nonsedative and long-acting histamine H1 antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$42	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$91	In Stock	In Stock
50 mg	$124	In Stock	In Stock
100 mg	$156	In Stock	-
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Mequitazine (Virginan) is an effective, nonsedative and long-acting histamine H1 antagonist.
In vitro	Mequitazine is widely studied and used for allergic disorders such as hay fever and urticaria[1]. Mequitazine demonstrates significant bactericidal effects against all the tested clinical isolates including Ps. aeruginosa. Its effect against the Gram-positive isolates is more pronounced [2].
In vivo	Mequitazine antagonizes the effect of histamine in guinea-pig ileum competitively. Mequitazine at 107 produces a parallel shift of the dose-response curve to acetylcholine in the rat duodenum. Mequitazine at highest concentration shows anticholinergic activity [3]. Mequitazine inhibits contractile responses to KCl, phenylephrine (PE), 5-hydroxytryptamine (5-HT), and Ca2+ in rat aorta [4].
Synonyms	Virginan, Primalan, Metaplexan, LM-209

Chemical Properties

Molecular Weight	322.47
Formula	C₂₀H₂₂N₂S
Cas No.	29216-28-2
Smiles	C(C1CN2CCC1CC2)N1c2ccccc2Sc2ccccc12
Relative Density.	1.28 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (155.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (7.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1011 mL	15.5053 mL	31.0106 mL	155.0532 mL
5 mM	0.6202 mL	3.1011 mL	6.2021 mL	31.0106 mL
10 mM	0.3101 mL	1.5505 mL	3.1011 mL	15.5053 mL
20 mM	0.1551 mL	0.7753 mL	1.5505 mL	7.7527 mL
50 mM	0.0620 mL	0.3101 mL	0.6202 mL	3.1011 mL
100 mM	0.0310 mL	0.1551 mL	0.3101 mL	1.5505 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc