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Anti-TNFR2/CD120b/TNFR1B Antibody (1J191) (Synonyms: tumor necrosis factor receptor superfamily, member 1b, TNF...)
Catalog No. TMAB-01874 Copy Product Info
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Anti-TNFR2/CD120b/TNFR1B Antibody (1J191) is a Rabbit antibody targeting TNFR2/CD120b/TNFR1B. Anti-TNFR2/CD120b/TNFR1B Antibody (1J191) can be used in IF,IHC-Fr,IHC-P.
Anti-TNFR2/CD120b/TNFR1B Antibody (1J191)
Copy Product Info🥰Excellent
Catalog No. TMAB-01874
Synonyms tumor necrosis factor receptor superfamily, member 1b, TNF-R-II, TNFR80, TNF-R75, TNFR2, TNFR1B, TNFBR, TBPII, p75TNFR, p75, CD120b
Anti-TNFR2/CD120b/TNFR1B Antibody (1J191) is a Rabbit antibody targeting TNFR2/CD120b/TNFR1B. Anti-TNFR2/CD120b/TNFR1B Antibody (1J191) can be used in IF,IHC-Fr,IHC-P.
Anti-TNFR2/CD120b/TNFR1B Antibody
(1J191)
(1J191)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $273 | 7-10 days | 7-10 days | |
| 100 μL | $487 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-TNFR2/CD120b/TNFR1B Antibody (1J191) is a Rabbit antibody targeting TNFR2/CD120b/TNFR1B. Anti-TNFR2/CD120b/TNFR1B Antibody (1J191) can be used in IF,IHC-Fr,IHC-P. |
| Synonyms | tumor necrosis factor receptor superfamily, member 1b, TNF-R-II, TNFR80, TNF-R75, TNFR2, TNFR1B, TNFBR, TBPII, p75TNFR, p75, CD120b |
| Ig Type | IgG |
| Clone | 1J191 |
| Reactivity | Human (predicted:Mouse,Rat) |
| Verified Activity | 1. Sample: Lane 1: Human THP-1 cell Lysates Lane 2: Human K562 cell Lysates Lane 3: Human U937 cell Lysates Lane 4: Human U87MG cell Lysates Lane 5: Human HUVEC cell Lysates Primary: Anti-TNFR2 (TMAB-01874) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 46 kDa Observed band size: 70 kDa 2. Paraformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TNFR2 Monoclonal Antibody, Unconjugated (TMAB-01874) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining. 3. Paraformaldehyde-fixed, paraffin embedded Human Chronic tonsillitis; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TNFR2 Monoclonal Antibody, Unconjugated (TMAB-01874) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining. 4. Paraformaldehyde-fixed, paraffin embedded Human Kidney Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TNFR2 Monoclonal Antibody, Unconjugated (TMAB-01874) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining.     |
| Application | |
| Recommended Dose | IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted and Cell membrane. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] |
| Immunogen | A synthesized peptide: human TNFRSF1B |
| Antigen Species | Human |
| Gene Name | TNFRSF1B |
| Gene ID | |
| Protein Name | Tumor necrosis factor receptor superfamily member 1B |
| Uniprot ID | |
| Function | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
| Molecular Weight | Theoretical: 46 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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