α-Conotoxin Vc1.1

Name: α-Conotoxin Vc1.1
Brand: TargetMol
SKU: T73894L
Rating: 4.5 (1 reviews)

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Catalog No. T73894LCas No. 913961-64-5

α-Conotoxin Vc1.1 are potent, short peptide neurotoxins derived from the venom of marine cone snails that selectively and competitively block nicotinic acetylcholine receptors (nAChRs) in the nervous system, serving as highly specific molecular probes to dissect nAChR subtype function and as promising drug discovery leads for pain management, oncology research, and neurological disorder studies by precisely modulating neurotransmission, inhibiting nerve signal propagation, and inducing controlled paralysis in experimental systems.

α-Conotoxin Vc1.1

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Catalog No. T73894LCas No. 913961-64-5

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Product Introduction

Bioactivity

Description	α-Conotoxin Vc1.1 are potent, short peptide neurotoxins derived from the venom of marine cone snails that selectively and competitively block nicotinic acetylcholine receptors (nAChRs) in the nervous system, serving as highly specific molecular probes to dissect nAChR subtype function and as promising drug discovery leads for pain management, oncology research, and neurological disorder studies by precisely modulating neurotransmission, inhibiting nerve signal propagation, and inducing controlled paralysis in experimental systems.
Targets&IC50	nAChR:~100 nM
In vitro	α-Conotoxin Vc1.1 effectively inhibiting the nicotine-induced release of catecholamines with an IC₅₀ in the nanomolar range (approximately 100 nM or lower), thereby confirming a significant blockade of cholinergic signal transmission.
In vivo	In rat saphenous nerve models, local perfusion of α-Conotoxin α-Conotoxin Vc1.1 significantly suppressed neurogenic inflammation—specifically vasodilation and plasma extravasation—induced by electrical stimulation of sensory C-fibers.

Chemical Properties

Molecular Weight	1811.01
Formula	C₇₁H₁₀₇N₂₃O₂₅S₄
Cas No.	913961-64-5
Smiles	C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CS)=O)CS)=O)CO)=O)CC(O)=O)=O)CCC3)CCCNC(=N)N)=O)CS)=O)CC(N)=O)=O)=O)CC(O)=O)=O)(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CS)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCC4
Relative Density.	no data available
Sequence	Glycyl-L-cysteinyl-L-cysteinyl-L-seryl-L-α-aspartyl-L-prolyl-L-arginyl-L-cysteinyl-L-asparaginyl-L-tyrosyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-glutamyl-L-isoleucyl-L-cysteinamide

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc