Anti-CILP Polyclonal Antibody

Name: Anti-CILP Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00434
Rating: 4.5 (1 reviews)

(Synonyms: CILP-1, CILP, Cartilage intermediate-layer protein, Cartilage intermediate layer protein 1) Copy Product Info

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Synonyms: CILP-1, CILP, Cartilage intermediate-layer protein, Cartilage intermediate layer protein 1

Catalog No. TMAB-00434 Copy Product Info

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Anti-CILP Polyclonal Antibody is a Rabbit antibody targeting CILP. Anti-CILP Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.

Anti-CILP Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$373	7-10 days	7-10 days
200 μL	$529	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-CILP Polyclonal Antibody is a Rabbit antibody targeting CILP. Anti-CILP Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Synonyms	CILP-1, CILP, Cartilage intermediate-layer protein, Cartilage intermediate layer protein 1
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Cow,Horse,Sheep)

Application	IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Secreted > extracellular space > extracellular matrix.
Tissue Specificity	Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human CILP
Antigen Species	Human
Gene Name	CILP
Gene ID	8483
Protein Name	Cartilage intermediate layer protein 1
Uniprot ID	O75339
Biology Area	Other ECM Proteins,Autoimmune
Function	Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.