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Pratol

Name: Pratol
Brand: TargetMol
SKU: TN3231
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN3231Cas No. 487-24-1

Alias 7-Hydroxy-4'-methoxyflavone

Pratol (7-Hydroxy-4'-methoxyflavone) significantly increased melanin content and tyrosinase activity in the cells without being cytotoxic.

Pratol

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Purity: 99.06%

Catalog No. TN3231Alias 7-Hydroxy-4'-methoxyflavoneCas No. 487-24-1

Pratol (7-Hydroxy-4'-methoxyflavone) significantly increased melanin content and tyrosinase activity in the cells without being cytotoxic.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	In Stock	In Stock
5 mg	$248	In Stock	In Stock
10 mg	$364	In Stock	In Stock
25 mg	$645	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$278	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.06%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Pratol AI Summary

Pratol exhibits a plethora of bioactivities across various assays. It inhibits COX-2 catalyzed PGE-2 production from LPS-induced RAW 264.7 cells at 10 μM with a 9.8% inhibition rate and shows antioxidant activity as evidenced by a delta absorbance of 0.23 in the MTT assay at 25 ppm. Demonstrating a diverse range of bioactivities, Pratol includes potency in erasing genomic imprints, modulating Menin-MLL interaction in leukemia, selectively targeting p53 mutant cancer cells, and regulating lipid storage. Additionally, it shows promising inhibitory effects on various enzymes like Cruzain, Cytochrome P450 enzymes (2C19, 3A4, 2C9), and electric eel AChE (30.64% at 2 mg/ml). Its inhibitory activity extends to viral enzymes, demonstrating efficacy against Lassa Virus, Marburg Virus, and Foot and Mouth Disease Virus. The compound significantly inhibits the ART domain of TNKS2 (IC50 ≈ 450 nM) and exhibits moderate inhibition of TNKS1 (IC50 ≈ 560 nM), with low activity against ARTD1 (IC50 > 100,000 nM). It also shows substantial inhibition of human recombinant glutaminyl cyclase at 100 μM (75.2% inhibition) and displays anti-glycosylation activity along with inhibition of rat brain AChE. Cumulatively, these data suggest that Pratol holds potential for therapeutic applications due to its multifaceted inhibitory and modulatory effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pratol (7-Hydroxy-4'-methoxyflavone) significantly increased melanin content and tyrosinase activity in the cells without being cytotoxic.
Synonyms	7-Hydroxy-4'-methoxyflavone

Chemical Properties

Molecular Weight	268.26
Formula	C₁₆H₁₂O₄
Cas No.	487-24-1
Smiles	O=C1C=2C(OC(=C1)C3=CC=C(OC)C=C3)=CC(O)=CC2
Relative Density.	1.329 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (242.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7277 mL	18.6386 mL	37.2773 mL	186.3863 mL
5 mM	0.7455 mL	3.7277 mL	7.4555 mL	37.2773 mL
10 mM	0.3728 mL	1.8639 mL	3.7277 mL	18.6386 mL
20 mM	0.1864 mL	0.9319 mL	1.8639 mL	9.3193 mL
50 mM	0.0746 mL	0.3728 mL	0.7455 mL	3.7277 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8639 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc