Anti-TAOK1 Antibody (8A980)

Anti-TAOK1 Antibody (8A980) is a Rabbit antibody targeting TAOK1. Anti-TAOK1 Antibody (8A980) can be used in WB.

IgG

8A980

Human,Mouse,Rat

25 ug total protein per lane of various lysates (see on figure) probed with TAOK1 monoclonal antibody, unconjugated (TMAB-13372) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.

WB=1:500-2000

Monoclonal

A synthesized peptide: human TAOK1

Human

TAOK1

Serine/threonine-protein kinase TAO1

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.