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Anti-SRPK1 Antibody (4L609)
😃Good
Catalog No. TMAY-02298
Alias SRSF protein kinase 1, SFRSK1, RP3-422H11.1
Anti-SRPK1 Antibody (4L609) is a Mouse antibody targeting SRPK1. Anti-SRPK1 Antibody (4L609) can be used in IHC-P.
Anti-SRPK1 Antibody (4L609)
Anti-SRPK1 Antibody (4L609)
😃Good
Catalog No. TMAY-02298Alias SRSF protein kinase 1, SFRSK1, RP3-422H11.1
Anti-SRPK1 Antibody (4L609) is a Mouse antibody targeting SRPK1. Anti-SRPK1 Antibody (4L609) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | SRSF protein kinase 1, SFRSK1, RP3-422H11.1 |
| Ig Type | Mouse IgG1 |
| Clone | 4L609 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human SRPK1 in human testis with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human SRPK1 in human rectum with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SRPK1 (rh SRPK1; TMPY-04567; AAH38292.1; Glu2-Ser655). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Serine / threonine-protein kinase SRPK1, also known as SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1 and SRPK1, is a cytoplasm and nucleus protein that belongs to the protein kinase superfamily and CMGC Ser/Thr protein kinase family. Isoform 2 of SRPK1 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 of SRPK1 is only seen in the testis, at lower levels than isoform 2. SRPK1 hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. SRPK1 plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. SRPK1 locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. SRPK1 appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human SRPK1 Protein (TMPY-04567) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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