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S-methyl-KE-298

Name: S-methyl-KE-298
Brand: TargetMol
SKU: T4282
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4282Cas No. 143584-75-2

S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.

S-methyl-KE-298

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Purity: 97.33%

Catalog No. T4282Cas No. 143584-75-2

Pack Size	Price	Availability
1 mg	$95	In Stock
5 mg	$233	In Stock
10 mg	$373	In Stock
25 mg	$689	In Stock
50 mg	$987	In Stock
100 mg	$1,390	In Stock
200 mg	$1,880	In Stock
1 mL x 10 mM (in DMSO)	$213	In Stock

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Batch Information

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Purity:97.33%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
In vitro	In vitro protein binding of S-methyl-KE-298 is high in rat (>97%), dog (>89%) and human plasma (>99%), respectively[2].

Chemical Properties

Molecular Weight	252.33
Formula	C₁₃H₁₆O₃S
Cas No.	143584-75-2
Smiles	C(CC(CSC)C(O)=O)(=O)C1=CC=C(C)C=C1
Relative Density.	1.188 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (396.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9631 mL	19.8153 mL	39.6306 mL	198.1532 mL
5 mM	0.7926 mL	3.9631 mL	7.9261 mL	39.6306 mL
10 mM	0.3963 mL	1.9815 mL	3.9631 mL	19.8153 mL
20 mM	0.1982 mL	0.9908 mL	1.9815 mL	9.9077 mL
50 mM	0.0793 mL	0.3963 mL	0.7926 mL	3.9631 mL
100 mM	0.0396 mL	0.1982 mL	0.3963 mL	1.9815 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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