Shopping Cart

Remove All
Your shopping cart is currently empty

Proceed to checkout Continue shopping

LEI-106

Name: LEI-106
Brand: TargetMol
SKU: T27811
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T27811Cas No. 1620582-23-1

Alias t-Boc-N-amido-PEG4-NHS ester

LEI-106 is an effective dual inhibitor of DAGL-α (sn-1-Diacylglycerol lipase α) and ABHD6 (α/β-hydrolase domain 6), with Ki values of 0.7 and 0.8 μM respectively, suitable for obesity and metabolic syndrome research.

LEI-106

😃Good

Catalog No. T27811Alias t-Boc-N-amido-PEG4-NHS esterCas No. 1620582-23-1

Pack Size	Price	Availability
1 mg	$163	35 days
5 mg	$482	35 days
10 mg	$848	35 days
25 mg	$1,830	35 days

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Resource Download

COA

Product Introduction

Bioactivity

Description	LEI-106 is an effective dual inhibitor of DAGL-α (sn-1-Diacylglycerol lipase α) and ABHD6 (α/β-hydrolase domain 6), with Ki values of 0.7 and 0.8 μM respectively, suitable for obesity and metabolic syndrome research.
Targets&IC50	ABHD6:0.8 μM (Ki), DAGLα:18 nM
In vivo	Methods: LEI-106 (40 mg/kg) was administered to female SD rats via intraperitoneal injection to investigate the effects of LEI-106 on the integrity of the blood-brain barrier (BBB). Result: LEI-106 reduced 2-AG levels by inhibiting DAGLα, thereby impairing the blood-brain barrier's integrity.[2]
Synonyms	t-Boc-N-amido-PEG4-NHS ester

Chemical Properties

Molecular Weight	481.56
Formula	C₂₆H₂₇NO₆S
Cas No.	1620582-23-1
Smiles	CC1(C)OC=2C(=CC(S(N(CC3=CC=C(OC4=CC=CC=C4)C=C3)CC(O)=O)(=O)=O)=CC2)CC1
Relative Density.	1.288 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc