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Glimepiride

Name: Glimepiride
Brand: TargetMol
SKU: T0127
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0127Cas No. 93479-97-1

Alias HOE-490, Glimperide

Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.

Glimepiride

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Purity: 98.87%

Catalog No. T0127Alias HOE-490, GlimperideCas No. 93479-97-1

Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$33	In Stock	In Stock
500 mg	$52	In Stock	In Stock
1 g	$88	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.87%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
Targets&IC50	SUR1:3 nM, SUR2A:5.4 nM, SUR2B:7.3 nM
In vitro	In both normal and insulin-resistant adipocytes, as well as in myocytes, Glimepiride effectively stimulates glucose transport, and the synthesis of lipids and glycogen. In cardiomyocytes, Glimepiride (IC50=6.8 nM) inhibits the pinacidil-activated whole-cell K(ATP) current. Additionally, in HEK 293 cells, Glimepiride (IC50=6.2 nM) blocks the K(ATP) channels formed by the co-expression of Kir6.2/SUR2A subunits.
In vivo	Within diabetic rats, Glimepiride has been shown to decrease the incidence of sperm abnormalities, enhance sperm count, and bolster antioxidant capacity.
Synonyms	HOE-490, Glimperide

Chemical Properties

Molecular Weight	490.62
Formula	C₂₄H₃₄N₄O₅S
Cas No.	93479-97-1
Smiles	C(NCCC1=CC=C(S(NC(N[C@H]2CC[C@H](C)CC2)=O)(=O)=O)C=C1)(=O)N3C(=O)C(CC)=C(C)C3
Relative Density.	1.29 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (61.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.5 mg/mL (3.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0382 mL	10.1912 mL	20.3824 mL	101.9119 mL
5 mM	0.4076 mL	2.0382 mL	4.0765 mL	20.3824 mL
10 mM	0.2038 mL	1.0191 mL	2.0382 mL	10.1912 mL
20 mM	0.1019 mL	0.5096 mL	1.0191 mL	5.0956 mL
50 mM	0.0408 mL	0.2038 mL	0.4076 mL	2.0382 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc