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SP-146

😃Good
Catalog No. T8685

SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).

SP-146

SP-146

😃Good
Purity: 97.82%
Catalog No. T8685
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$80In StockIn Stock
5 mg$178In StockIn Stock
10 mg$272In StockIn Stock
25 mg$448In StockIn Stock
50 mg$630In StockIn Stock
100 mg$852In StockIn Stock
200 mg$1,130-In Stock
1 mL x 10 mM (in DMSO)$187In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:97.82%
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Product Introduction

Bioactivity
Description
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).
Targets&IC50
Aurora B (cell-free assay):0.316 nM
Chemical Properties
Molecular Weight453.47
FormulaC25H20FN7O
SmilesCn1cc(cn1)c2ccc5c(c2)ncnc5Nc4cccc(NC(=O)Nc3cccc(F)c3)c4
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 91 mg/mL (200.67 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2052 mL11.0261 mL22.0522 mL110.2609 mL
5 mM0.4410 mL2.2052 mL4.4104 mL22.0522 mL
10 mM0.2205 mL1.1026 mL2.2052 mL11.0261 mL
20 mM0.1103 mL0.5513 mL1.1026 mL5.5130 mL
50 mM0.0441 mL0.2205 mL0.4410 mL2.2052 mL
100 mM0.0221 mL0.1103 mL0.2205 mL1.1026 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SP-146SP146SP 146AuroraKinaseAurora KinaseAurora B
Related Tags: buy SP-146 | purchase SP-146 | SP-146 cost | order SP-146 | SP-146 chemical structure | SP-146 formula | SP-146 molecular weight
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