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Bay K 8644

Name: Bay K 8644
Brand: TargetMol
SKU: T6777
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6777Cas No. 71145-03-4

Alias SQ 28,873, (±)-BAY-K-8644

Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.

Bay K 8644

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Purity: 99.41%

Catalog No. T6777Alias SQ 28,873, (±)-BAY-K-8644Cas No. 71145-03-4

Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$80	In Stock
10 mg	$128	In Stock
25 mg	$263	In Stock
50 mg	$416	In Stock
100 mg	$618	In Stock

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Batch Information

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Purity:99.41%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.
Targets&IC50	Ca2+ channel, L-type:17.3nM(EC50)
In vitro	Bay K 8644 increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel[2]
In vivo	Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.[3]
Synonyms	SQ 28,873, (±)-BAY-K-8644

Chemical Properties

Molecular Weight	356.3
Formula	C₁₆H₁₅F₃N₂O₄
Cas No.	71145-03-4
Smiles	COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1C(F)(F)F)[N+]([O-])=O
Relative Density.	1.3548 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.2 mg/mL (insoluble)

Ethanol: 35.6 mg/mL (99.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8066 mL	14.0331 mL	28.0662 mL	140.3312 mL
5 mM	0.5613 mL	2.8066 mL	5.6132 mL	28.0662 mL
10 mM	0.2807 mL	1.4033 mL	2.8066 mL	14.0331 mL
20 mM	0.1403 mL	0.7017 mL	1.4033 mL	7.0166 mL
50 mM	0.0561 mL	0.2807 mL	0.5613 mL	2.8066 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc