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Anti-Phospho-RPS6KA5 (Ser376) Antibody (7N405)
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Catalog No. TMAH-00961
Alias S6K-alpha-5, S6K alpha 5, RSK-like protein kinase, RSKL, RSK Like Protein Kinase, RLPK, Ribosomal protein S6 kinase alpha-5, Ribosomal Protein S6 Kinase Alpha 5, Ribosomal protein S6 kinase 90kD polypeptide 5, Phospho-RPS6KA5 (S376), Nuclear Mitogen And Stress Activated Protein Kinase 1, MSPK1, Mitogen and stress activated protein kinase 1, MGC1911, KS6A5_HUMAN, EC 2.7.11.1, 90 kDa ribosomal protein S6 kinase 5
Anti-Phospho-RPS6KA5 (Ser376) Antibody (7N405) is an antibody targeting Phospho-RPS6KA5 (Ser376). Anti-Phospho-RPS6KA5 (Ser376) Antibody (7N405) can be used in ELISA, IHC.
Anti-Phospho-RPS6KA5 (Ser376) Antibody (7N405)
Anti-Phospho-RPS6KA5 (Ser376) Antibody (7N405)
😃Good
Catalog No. TMAH-00961Alias S6K-alpha-5, S6K alpha 5, RSK-like protein kinase, RSKL, RSK Like Protein Kinase, RLPK, Ribosomal protein S6 kinase alpha-5, Ribosomal Protein S6 Kinase Alpha 5, Ribosomal protein S6 kinase 90kD polypeptide 5, Phospho-RPS6KA5 (S376), Nuclear Mitogen And Stress Activated Protein Kinase 1, MSPK1, Mitogen and stress activated protein kinase 1, MGC1911, KS6A5_HUMAN, EC 2.7.11.1, 90 kDa ribosomal protein S6 kinase 5
Anti-Phospho-RPS6KA5 (Ser376) Antibody (7N405) is an antibody targeting Phospho-RPS6KA5 (Ser376). Anti-Phospho-RPS6KA5 (Ser376) Antibody (7N405) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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| Description | Anti-Phospho-RPS6KA5 (Ser376) Antibody (7N405) is an antibody targeting Phospho-RPS6KA5 (Ser376). Anti-Phospho-RPS6KA5 (Ser376) Antibody (7N405) can be used in ELISA, IHC. |
| Alias | S6K-alpha-5, S6K alpha 5, RSK-like protein kinase, RSKL, RSK Like Protein Kinase, RLPK, Ribosomal protein S6 kinase alpha-5, Ribosomal Protein S6 Kinase Alpha 5, Ribosomal protein S6 kinase 90kD polypeptide 5, Phospho-RPS6KA5 (S376), Nuclear Mitogen And Stress Activated Protein Kinase 1, MSPK1, Mitogen and stress activated protein kinase 1, MGC1911, KS6A5_HUMAN, EC 2.7.11.1, 90 kDa ribosomal protein S6 kinase 5 |
| Ig Type | Rabbit IgG |
| Clone | 7N405 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00961 diluted at 1:100 and staining in paraffin-embedded human bladder cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury. Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-RPS6KA5 (S376) |
| Antigen Species | Human |
| Gene ID | 9252 |
| Uniprot ID | |
| Biology Area | Signal Transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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