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Sigma-1 receptor antagonist 1
🥰Excellent
Catalog No. T12910Cas No. 1639220-19-1
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studies.
Sigma-1 receptor antagonist 1
🥰Excellent
Purity: 99.92%
Catalog No. T12910Cas No. 1639220-19-1
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studies.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $148 | In Stock | |
| 10 mg | $238 | In Stock | |
| 25 mg | $398 | In Stock | |
| 50 mg | $567 | In Stock | |
| 100 mg | $768 | In Stock | |
| 200 mg | $987 | In Stock |
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Purity:99.92%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studies. |
| Targets&IC50 | σ1 receptor:1.06 nM(Ki) |
| In vitro | Sigma‑1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor with Ki of 1.06 nM and good σ-1/2 selectivity (1344-fold)[1]. |
| In vivo | In mice formalin model and rats CCI models of neuropathic pain, Sigma‑1 receptor antagonist 1 exerts dose-dependent antinociceptive effects[1]. |
| Molecular Weight | 380.31 |
| Formula | C19H23Cl2N3O |
| Cas No. | 1639220-19-1 |
| Smiles | Cc1nc(nc(OCCCN2CCCCC2)c1Cl)-c1ccc(Cl)cc1 |
| Relative Density. | 1.219 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.  |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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