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2,5-Dihydroxybiphenyl
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Catalog No. T21082Cas No. 1079-21-6
Alias TFIIH Modulator12, TFIIH Modulator 12
2,5-Dihydroxybiphenyl (TFIIH Modulator12), a small molecule destabilization inducer, induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity.
2,5-Dihydroxybiphenyl
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Purity: 99.66%
Catalog No. T21082Alias TFIIH Modulator12, TFIIH Modulator 12Cas No. 1079-21-6
2,5-Dihydroxybiphenyl (TFIIH Modulator12), a small molecule destabilization inducer, induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $29 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.66%
Appearance:Solid
Color:Cyan
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Product Introduction
2,5-Dihydroxybiphenyl AI Summary
2,5-Dihydroxybiphenyl inhibits the Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) in rabbit hind leg tissue microsomes, affecting ATP hydrolysis with an IC50 value of 2290.0 nM. The inhibition was assessed by measuring the rate of NADH oxidation coupled to SERCA-catalyzed ATP hydrolysis using a spectroscopic assay. Additionally, 2,5-Dihydroxybiphenyl exhibits bioactivity as an inhibitor of recombinant human IDO1 expressed in Escherichia coli EC538, demonstrating a 65.0% inhibition of the enzyme's activity using L-tryptophan as the substrate after 1 hour..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 2,5-Dihydroxybiphenyl (TFIIH Modulator12), a small molecule destabilization inducer, induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity. |
| Synonyms | TFIIH Modulator12, TFIIH Modulator 12 |
| Molecular Weight | 186.21 |
| Formula | C12H10O2 |
| Cas No. | 1079-21-6 |
| Smiles | Oc1ccc(O)c(c1)-c1ccccc1 |
| Relative Density. | 1.228g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 1.87 mg/mL (10.04 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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