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K1-70 (Alias: Anti-TSHR Antibody (K1-70))
Catalog No. T77360 Copy Product Info
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K1-70 is a humanized antibody targeting TSHR, used in the study of autoimmune diseases and endocrine disorders.
K1-70
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Catalog No. T77360
Alias Anti-TSHR Antibody (K1-70)
K1-70 is a humanized antibody targeting TSHR, used in the study of autoimmune diseases and endocrine disorders.
K1-70
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $125 | - | In Stock | |
| 5 mg | $398 | - | In Stock | |
| 10 mg | $639 | - | In Stock | |
| 25 mg | $1,086 | - | In Stock | |
| 50 mg | $1,629 | - | In Stock |
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:>95.0% (SDS-PAGE); 98.09% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
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| Description | K1-70 is a humanized antibody targeting TSHR, used in the study of autoimmune diseases and endocrine disorders. |
| Targets&IC50 | TSHR (human):851.2 ng/mL (EC50) |
| In vitro | K1-70 is the most potent inhibitor of TSH binding to the receptor, producing 97% inhibition as low as 0.1 μg/mL. [1] K1-70 (0.1 μg/ ml-0.5 μg/mL) inhibited the cyclic AMP stimulating activity of M22 IgG (3 ng/mL) in a dose-dependent manner in CHO cells expressing TSHR. [2] |
| In vivo | K1-70 (100-200 μg) caused serum total and free T4 to decrease to the low levels observed in T3 inhibited rats. [1] |
| Synonyms | Anti-TSHR Antibody (K1-70) |
| Clone | K1-70 |
| Reactivity | Human |
| Verified Activity | Immobilized TSHR-VLP at 2 μg/mL can bind K1-70. The EC50 is 0.8512 μg/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TSHR/LGR3 |
| Molecular Weight | 143.54 kDa |
| Smiles | #N/A |
| Isotype | Human IgG1 lambda |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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