CaSR

Poly-D-lysine hydrobromide (MW 30000-70000) (Poly-D-lysine HBr) is an oral peptide CaSR agonist that eliminates proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells.

Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.

Calindol hydrochloride is a potent orthosteric modulator (EC50: 132 nM) of the putative calcium-calcium-sensitive receptor (CaSR), inhibits Pi-induced VC, and delays the progression of calcification in vascular smooth muscle cells.

Ligustroflavone (Nuezhenoside) has anti-inflammatory activity.

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist

Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist used in the treatment of cardiovascular disease.

Cinacalcet hydrochloride (AMG-073 hydrochloride) is a naphthalene derivative and calcimimetic agent that enhances the sensitivity of parathyroid gland calcium-sensing receptors to serum calcium, thereby reducing parathyroid hormone secretion and decreasing serum calcium in the treatment of parathyroid diseases.

Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+.

Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-sensitive receptors, thereby lowering blood levels of PTH.Upacicalcet is an orthosteric modulator of calcium-sensitive receptors and prevents adenine-induced secondary vascular calcification and bone disease in a rat model of adenine-induced secondary hyperparathyroidism.

Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide that serves as an allosteric modulator of the calcium-sensing receptor (CaSR), effectively reducing parathyroid hormone (PTH) levels in patients with secondary hyperparathyroidism undergoing hemodialysis.

Calhex 231 hydrochloride is the salt form of Calhex 231, a potent calcium-sensing receptor (CaSR) negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits oxidative stress and mir-208a-mediated mitochondrial fission for vasculoprotection and treatment of traumatic hemorrhagic shock.

SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.

Strontium chloride is an agonist of Calcium sensing receptor (CaSR) and directly affects C-type nerve fibers.

NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist.

Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a dual action bone agent (DABA) indicated for use in the treatment of severe osteoporosis.

NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)

AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity that inhibits neuroblastoma tumour growth by inducing differentiation.AC265347 can be used to study neuroblastoma.

NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.

TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity.

γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is the substrate of CRF21 [gamma-Glutamylcyclotransferase (GGCT)].

Evocalcet (KHK7580) has an activating effect on the calcium-sensing receptor (CaSR).

Upacicalcet HCl is an intravesical calcium mimetic that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on calcium-sensitive receptors in parathyroid cell membranes, thereby lowering PTH levels in the blood.Upacicalcet HCl can be used for the treatment of blood Upacicalcet HCl is a novel compound for the treatment of secondary hyperparathyroidism, targeting amino acid-binding sites of calcium-sensitive receptors. binding sites.

Poly-D-lysine hydrobromide (MW 150000-300000), is a synthetic polymeric substrate widely used in neural cell culture to enhance cell adhesion. Poly-D-lysine hydrobromide additionally functions as a calcium-sensing receptor (CaSR) agonist peptide, broadening its relevance in both cell biology and neurobiological research applications.

L-Phenylalanine (Standard) is an essential alpha-amino acid used as a standard for quantitative analysis.L-Phenylalanine is an agonist of GPR142 and promotes insulin secretion, which is closely related to glucose metabolism and diabetes research. L-Phenylalanine is an agonist of GPR142 and promotes insulin secretion, which has been implicated in studies of glucose metabolism and diabetes. May indirectly regulate N-methyl-D-aspartate receptors (NMDA receptors) by affecting dopamine levels.