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Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody is a Rabbit antibody targeting Phospho-C-ABL/ABL1 (Thr735). Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody can be used in WB.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $218 | 7-10 days | |
100 μL | $318 | 7-10 days |
Description | Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody is a Rabbit antibody targeting Phospho-C-ABL/ABL1 (Thr735). Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody can be used in WB. |
Ig Type | IgG |
Reactivity | Human |
Application | |
Recommended Dose | WB: 1:500-1000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Construction | Polyclonal Antibody |
Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
Appearance | Liquid |
Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Research Background | The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. |
Conjucates | Unconjugated |
Others Formats | Phospho |
Immunogen | Peptide sequence around phosphorylation site of threonine735 (S-V-T(p)-L-P) derived from Human ABL1 |
Antigen Species | human |
Uniprot ID |
Molecular Weight | Actual: 135 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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