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Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody 2

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Catalog No. TMAC-00047

Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody is a Rabbit antibody targeting Phospho-C-ABL/ABL1 (Thr735). Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody can be used in WB.

Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody 2

Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody 2

😃Good
Catalog No. TMAC-00047
Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody is a Rabbit antibody targeting Phospho-C-ABL/ABL1 (Thr735). Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2187-10 days
100 μL$3187-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody is a Rabbit antibody targeting Phospho-C-ABL/ABL1 (Thr735). Anti-Phospho-C-ABL/ABL1 (Thr735) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:500-1000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundThe ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of threonine735 (S-V-T(p)-L-P) derived from Human ABL1
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 135 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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