Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PqsR-IN-1 (Compound 18) is a potent inhibitor of PqsR, which is a transcriptional regulator involved in the quorum sensing mechanism of Pseudomonas aeruginosa. This compound effectively reduces the production of pyocyanin and exhibits minimal cytotoxicity [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | PqsR-IN-1 (Compound 18) is a potent inhibitor of PqsR, which is a transcriptional regulator involved in the quorum sensing mechanism of Pseudomonas aeruginosa. This compound effectively reduces the production of pyocyanin and exhibits minimal cytotoxicity [1]. |
In vitro | PqsR-IN-1 (Compound 18) effectively inhibits the pqs system in Pseudomonas aeruginosa, demonstrating IC50 values of 313 ± 156.2 nM and 342 ± 39.4 nM against PAO1-L and PA14 strains, respectively [1]. Additionally, at three times the IC50 value, this compound markedly decreases pyocyanin production to 23% in the PAO1-L strain, compared to a 0.1% DMSO control [1]. Furthermore, PqsR-IN-1 exhibits minimal toxicity towards A549 lung epithelial cells, with no significant adverse effects noted across a range of concentrations (0-100 μM) after 16 hours of exposure [1]. |
Molecular Weight | 347.86 |
Formula | C17H18ClN3OS |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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