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PARP/PI3K-IN-1

Name: PARP/PI3K-IN-1
Brand: TargetMol
SKU: T12365
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12365Cas No. 2337386-47-5

PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers.

PARP/PI3K-IN-1

🥰Excellent

Purity: 99.59%

Catalog No. T12365Cas No. 2337386-47-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
5 mg	$255	In Stock	In Stock
10 mg	$396	In Stock	In Stock
25 mg	$689	In Stock	In Stock
50 mg	$1,070	In Stock	In Stock
100 mg	$1,450	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.59%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers.
Targets&IC50	PI3Kγ:6.08 (pIC50), PI3Kδ:8.13 (pIC50), PARP1:8.22 (pIC50), PI3Kβ:6.54 (pIC50), PI3Kα:8.25 (pIC50), PARP2:8.44 (pIC50)
In vitro	PARP/PI3K-IN-1 (1 μM; 72 h) decreased the levels of self-phosphorylation of AKT and S6, while increasing the phosphorylation levels of ERK following treatment, indicating the inhibition of the PI3K pathway and activation of the ERK pathway by PARP/PI3K-IN-1, resulting in significantly increased apoptosis.[1]. In BRCA-deficient cells, PARP/PI3K-IN-1 not only exhibits significant inhibitory activity against HCC1937 and HCT116, but also demonstrates anti-proliferative activity against MDA-MB-231 and MDA-MB-468 [1].
In vivo	PARP/PI3K-IN-1 (IP; 50 mg/kg; treatment for 34 days) significantly inhibits tumor growth[1].

Chemical Properties

Molecular Weight	660.62
Formula	C₃₃H₂₈F₄N₈O₃
Cas No.	2337386-47-5
Smiles	O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CC5=NC(=NC(=C5CC4)N6CCOCC6)C7=CN=C(N)C=C7C(F)(F)F
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (121.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5137 mL	7.5686 mL	15.1373 mL	75.6865 mL
5 mM	0.3027 mL	1.5137 mL	3.0275 mL	15.1373 mL
10 mM	0.1514 mL	0.7569 mL	1.5137 mL	7.5686 mL
20 mM	0.0757 mL	0.3784 mL	0.7569 mL	3.7843 mL
50 mM	0.0303 mL	0.1514 mL	0.3027 mL	1.5137 mL
100 mM	0.0151 mL	0.0757 mL	0.1514 mL	0.7569 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc