Shopping Cart

Your shopping cart is currently empty

RS-1

Name: RS-1
Brand: TargetMol
SKU: T6972
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T6972Cas No. 312756-74-4

RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.

RS-1

Copy Product Info

😃Good

Purity: 99.7%

Catalog No. T6972Cas No. 312756-74-4

RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$47	In Stock	In Stock
10 mg	$66	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$153	In Stock	In Stock
100 mg	$208	In Stock	In Stock
200 mg	$312	-	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.7%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.

In vitro

RS-1 serves as an activator of RAD51, enhancing the binding affinity of hRAD51 to DNA, with a dissociation constant (Kd) between 48 nM and 107 nM, in conditions containing ATP or ADP and even in the absence of nucleotide cofactors, without inhibiting ATPase activity of RAD51. At a concentration of 20 μM, RS-1 alters the length and helical pitch of hRAD51-DNA complexes. Furthermore, RS-1 progressively augments the strand assimilation activity of hRAD51 across a range of concentrations (0, 1, 5, 10, 15, 20, and 25 μM). At 7.5 μM, it bolsters human cells' resilience to cross-linking agents used in chemotherapy[1]. In addition, RS-1 enhances Cas9-mediated gene editing efficiency in rabbit embryos at concentrations of 0, 7.5, and 15 μM[2].

Chemical Properties

Molecular Weight	524.23
Formula	C₂₀H₁₆Br₂N₂O₃S
Cas No.	312756-74-4
Smiles	Brc1ccc(NC(=O)c2ccc(Br)c(c2)S(=O)(=O)NCc2ccccc2)cc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (476.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (4.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9076 mL	9.5378 mL	19.0756 mL	95.3780 mL
5 mM	0.3815 mL	1.9076 mL	3.8151 mL	19.0756 mL
10 mM	0.1908 mL	0.9538 mL	1.9076 mL	9.5378 mL
20 mM	0.0954 mL	0.4769 mL	0.9538 mL	4.7689 mL
50 mM	0.0382 mL	0.1908 mL	0.3815 mL	1.9076 mL
100 mM	0.0191 mL	0.0954 mL	0.1908 mL	0.9538 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc