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SM-276001

Name: SM-276001
Brand: TargetMol
SKU: T12933
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12933Cas No. 473930-22-2

SM-276001 is a potent, selective agonist of TLR7 and an orally active interferon (IFN) inducer.

SM-276001

🥰Excellent

Purity: 99.91%

Catalog No. T12933Cas No. 473930-22-2

SM-276001 is a potent, selective agonist of TLR7 and an orally active interferon (IFN) inducer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	In Stock	In Stock
5 mg	$142	In Stock	In Stock
10 mg	$213	In Stock	In Stock
25 mg	$383	In Stock	In Stock
50 mg	$575	In Stock	In Stock
100 mg	$833	In Stock	In Stock
200 mg	$1,120	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$155	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SM-276001 is a potent, selective agonist of TLR7 and an orally active interferon (IFN) inducer.
In vitro	SM-276001 (1 nM-10 μM) activates NF-κB in a dose-dependent manner via human TLR7 [2].
In vivo	Oral administration of 0.1 mg/kg SM-276001 in mice shows potent IFN-inducing activity [1]. Twice weekly oral administration of SM-276001 at a dose of 3 mg/kg significantly reduced disease burden in mice bearing either Renca or CT26 tumors.[2].

Chemical Properties

Molecular Weight	327.38
Formula	C₁₆H₂₁N₇O
Cas No.	473930-22-2
Smiles	CCCCNc1nc(N)c2[nH]c(=O)n(Cc3ccc(C)nc3)c2n1
Relative Density.	1.322 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (305.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0546 mL	15.2728 mL	30.5455 mL	152.7277 mL
5 mM	0.6109 mL	3.0546 mL	6.1091 mL	30.5455 mL
10 mM	0.3055 mL	1.5273 mL	3.0546 mL	15.2728 mL
20 mM	0.1527 mL	0.7636 mL	1.5273 mL	7.6364 mL
50 mM	0.0611 mL	0.3055 mL	0.6109 mL	3.0546 mL
100 mM	0.0305 mL	0.1527 mL	0.3055 mL	1.5273 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc