TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His & Avi)

Catalog No. TMPK-00706

TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is O00220.

TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His & Avi)

Catalog No. TMPK-00706

Pack Size	Price	Availability
5 μg	$43	7-10 days
10 μg	$66	7-10 days
20 μg	$105	7-10 days
50 μg	$197	7-10 days
100 μg	$336	7-10 days
200 μg	$596	7-10 days
500 μg	$1,350	7-10 days

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Product Information

Biological Activity	Human TRAIL R1, His Tag captured on CM5 Chip via anti-his antibody can bind Human TRAIL, No Tag with an affinity constant of 1.02 nM as determined in SPR assay.
Description	TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is O00220.
Species	Human
Expression System	HEK293 Cells
Tag	C-His-Avi
Accession Number	O00220
Synonyms	TRAIL-R,TRAIL R1,TNFRSF10A,MGC9365,DR4,CD261,APO2
Construction	Pro34-Asn239
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	24.7 kDa (predicted). Due to glycosylation, the protein migrates to 25-30 kDa based on Tris-Bis PAGE result.
Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily.The expression of apoptosis-inducing TRAIL-R1 and TRAIL-R2 and of the decoy receptors TRAIL-R3 and TRAIL-R4 was systematically studied in all developmental stages of peripheral B cells isolated from the blood and secondary lymphoid organs. Expression of TRAIL-Rs is modulated along development, with highest levels observed in germinal center B cells.