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LysRs-IN-2

Name: LysRs-IN-2
Brand: TargetMol
SKU: T11920
Price: 112 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11920Cas No. 2170696-76-9

LysRs-IN-2 is a lysine tRNA synthetase (KRS) inhibitor with antiparasitic activity that inhibits Plasmodium falciparum KRS (PfKRS) and Cryptosporidium minum KRS (CpKRS), and is used in the study of malaria infections.

LysRs-IN-2

🥰Excellent

Purity: 99.34%

Catalog No. T11920Cas No. 2170696-76-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$112	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$519	In Stock	In Stock
25 mg	$833	In Stock	In Stock
50 mg	$1,130	In Stock	In Stock
100 mg	$1,530	In Stock	In Stock
200 mg	$1,980	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.34%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	LysRs-IN-2 is a lysine tRNA synthetase (KRS) inhibitor with antiparasitic activity that inhibits Plasmodium falciparum KRS (PfKRS) and Cryptosporidium minum KRS (CpKRS), and is used in the study of malaria infections.
Targets&IC50	CpKRS:0.13 μM, Cryptosporidium minis:2.5 μM (EC50), PfKRS:0.015 μM, P. falciparum strain 3D7:0.27 μM (EC50), HepG2 cells:49 μM (EC50), lysyl-tRNA synthetase (HsKRS) (human):1.8 μM
In vitro	LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with half inhibitory concentrations (IC50) of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium lysyl-tRNA synthetase (CpKRS) respectively.[1] LysRs-IN-2 showed significant activity against P. falciparum strain 3D7 (EC50=0.27 μM), human lysyl-tRNA synthetase (HsKRS) (IC50=1.8 μM), HepG2 cells (EC50=49 μM), and Cryptosporidium minis (EC50=2.5 μM) in a whole-cell assay. [1]
In vivo	In the P. falciparum SCID mouse model, LysRs-IN-2 (1.5 mg/kg; orally once daily for 4 days) reduced parasitemia levels by 90%. In NOD SCID gamma mice and INF-γ knockout mice (Cryptosporidium minis model), LysRs-IN-2 (20 mg/kg; orally once daily for 7 days) significantly reduced parasite excretion. [1]

Chemical Properties

Molecular Weight	355.31
Formula	C₁₇H₁₆F₃NO₄
Cas No.	2170696-76-9
Smiles	O=C1C=C(OC2=CC=C(F)C=C12)C(=O)NCC3(O)CCC(F)(F)CC3
Relative Density.	1.44 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (140.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8144 mL	14.0722 mL	28.1444 mL	140.7222 mL
5 mM	0.5629 mL	2.8144 mL	5.6289 mL	28.1444 mL
10 mM	0.2814 mL	1.4072 mL	2.8144 mL	14.0722 mL
20 mM	0.1407 mL	0.7036 mL	1.4072 mL	7.0361 mL
50 mM	0.0563 mL	0.2814 mL	0.5629 mL	2.8144 mL
100 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4072 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PfKRSLysRs-IN-2LysRsIN2LysRs IN 2CpKRS