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Enzyme-Linked Receptors

Enzyme-Linked Receptors are transmembrane receptors, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side. Hence an enzyme-linked receptor is an integral membrane protein possessing both catalytic, and receptor functions. Most enzyme-linked receptors are receptor tyrosine kinase.They have two important domains, an extra-cellular ligand binding domain and an intracellular domain, which has a catalytic function,and a single transmembrane helix. The signaling molecule binds to the receptor on the outside of the cell and causes a conformational change on the catalytic function located on the receptor inside the cell.

  • FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc)
    TMPJ-00391
    FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802-3.
    • $86
    7-10 days
    Size
    QTY
  • EphB2 Protein, Human, Recombinant (hFc)
    TMPJ-00424
    Ephrin type-B receptor 2(EPHB2) belongs to the protein kinase superfamily and Ephrin receptor subfamily. EPHB2 contains 1 Eph LBD domain, 2 fibronectin type-III domains, 1 protein kinase domain and 1 SAM domain. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family.
    • $110
    7-10 days
    Size
    QTY
  • ACVR2A Protein, Human, Recombinant (hFc & His)
    TMPJ-00315
    Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
    • $60
    7-10 days
    Size
    QTY
  • TIE2 Protein, Human, Recombinant (hFc)
    TMPJ-00642
    TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1.
    • $60
    7-10 days
    Size
    QTY
  • MERTK/Mer Protein, Human, Recombinant (aa 1-323, His)
    TMPJ-01143
    Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that the MERTK plays critical role in the engulfment and efficient clearance of apoptotic cells, platelet aggregation, and cytoskeleton reorganization. Not only these, it also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. In addition, MERTK could regulate rod outer segments fragments phagocytosis in the retinal pigment epithelium (RPE), deficiency in MERTK are the cause of retinitis pigmentosa.
    • $184
    7-10 days
    Size
    QTY
  • TGFBR1 Protein, Mouse, Recombinant (hFc)
    TMPJ-01178
    TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. TGF-beta RI is likely important during development, since mice deficient for TGF-beta RI die at midgestation with severe defects in vascular development of the yolk sac and placenta, and an absence of circulating red blood cells. Furthermore, TGF-beta RI appears to be involved in proper lymphatic network development.
    • $140
    7-10 days
    Size
    QTY
  • HER4/ERBB4 Protein, Human, Recombinant (His & Avi)
    TMPK-00448
    Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS. HER4/ERBB4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 72.7 kDa and the accession number is Q15303-1.
    • $347
    7-10 days
    Size
    QTY
  • HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled
    TMPK-00452
    Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession number is P21860-1.
    • $932
    7-10 days
    Size
    QTY
  • HER3/ERBB3 Protein, Human, Recombinant (His & Avi)
    TMPK-00453
    Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession number is P21860-1.
    • $278
    7-10 days
    Size
    QTY
  • FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00381
    FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22455-1.
    • $814
    7-10 days
    Size
    QTY
  • FGFR4 Protein, Human, Recombinant (His & Avi)
    TMPK-00379
    FGFR4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22455-1.
    • $231
    7-10 days
    Size
    QTY
  • FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00391
    Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis.
    • $814
    7-10 days
    Size
    QTY
  • FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)
    TMPK-00392
    Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession number is P11362-7.
    • $347
    7-10 days
    Size
    QTY
  • FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)
    TMPK-00398
    FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
    • $534
    7-10 days
    Size
    QTY
  • FGFR2 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00401
    Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs.
    • $814
    7-10 days
    Size
    QTY
  • FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00380
    FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.90 kDa and the accession number is P22455-1.
    • $814
    7-10 days
    Size
    QTY
  • FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi)
    TMPK-00384
    FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.1 kDa and the accession number is P22607.
    • $347
    7-10 days
    Size
    QTY
  • PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00420
    Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two receptors PDGF-alpha R and PDGF-beta R are known to bind PDGF. PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59.2 kDa and the accession number is P16234.
    • $814
    7-10 days
    Size
    QTY
  • FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His)
    TMPK-00686
    FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 37.09 kDa and the accession number is E9QNJ9.
    • $418
    7-10 days
    Size
    QTY
  • HGFR/c-Met Protein, Cynomolgus, Recombinant (His)
    TMPK-00499
    c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 32.5 kDa (α chain) and 69.9 kDa (β chain) and the accession number is A0A2K5UM36.
    • $487
    7-10 days
    Size
    QTY
  • ROR2 Protein, Human, Recombinant (hFc)
    TMPK-00579
    ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the development of the central nervous system. Mature human ROR2 contains a 369 amino acid (aa) extracellular domain (ECD) and a 518 aa cytoplasmic tail containing an tyrosine kinase domain. ROR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 68 kDa and the accession number is A1L4F5.
    • $487
    7-10 days
    Size
    QTY
  • FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His)
    TMPK-00847
    FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.3 kDa and the accession number is P21803-2.
    • $487
    7-10 days
    Size
    QTY
  • PDGF R beta/CD140b Protein, Canine, Recombinant (His)
    TMPK-01050
    PDGF R beta/CD140b Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 57.25 kDa and the accession number is Q6QNF3.
    • $487
    7-10 days
    Size
    QTY
  • EPHA5 Protein, Human, Recombinant (His)
    TMPK-00899
    Ephrin type-A receptor 5 (EphA5) expression was detected in all non-tumor gastric epithelia but was differentially expressed among gastric cancer samples. EphA5 is differentially expressed in gastric cancer. EphA5 may therefore be a potential therapeutic target and may have clinical utility as a marker for lymph node metastasis in gastric cancer. EPHA5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 61.9 kDa and the accession number is P54756-1.
    • $487
    7-10 days
    Size
    QTY
  • TYRO3 Protein, Mouse, Recombinant (His)
    TMPK-00901
    TYRO3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 43 kDa and the accession number is P55144-2.
    • $418
    7-10 days
    Size
    QTY
  • PDGF R alpha/PDGFRA Protein, Cynomolgus, Recombinant (His)
    TMPK-00943
    Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two receptors PDGF-alpha R and PDGF-beta R are known to bind PDGF. PDGF R alpha/PDGFRA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 57.32 kDa and the accession number is Q0PW86.
    • $487
    7-10 days
    Size
    QTY
  • FLT1 Protein, Human, Recombinant (hFc)
    TMPY-00119
    FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is P17948-4.
    • $398
    7-10 days
    Size
    QTY
  • ALK-1 Protein, Cynomolgus, Recombinant (His)
    TMPY-00310
    ALK-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.2 kDa and the accession number is A0A2K5WXU2.
    • $600
    7-10 days
    Size
    QTY
  • BMPR1A/ALK-3 Protein, Canine, Recombinant (hFc)
    TMPY-00614
    BMPR1A/ALK-3 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.2 kDa and the accession number is A0A8C0S7K5.
    • $398
    7-10 days
    Size
    QTY
  • HER2/ERBB2 Protein, Cynomolgus, Recombinant (His)
    TMPY-00636
    HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is G7PUM4.
    • $386
    In Stock
    Size
    QTY
  • TrkB Protein, Human, Recombinant (His)
    TMPY-00751
    TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
    • $228
    In Stock
    Size
    QTY
  • ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc)
    TMPY-00658
    ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is D3DPA4.
    • $904
    7-10 days
    Size
    QTY
  • FGFR4 Protein, Mouse, Recombinant (His & hFc)
    TMPY-01019
    FGFR4 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67 kDa and the accession number is A0A0R4IZY3.
    • $600
    7-10 days
    Size
    QTY
  • AXL Protein, Mouse, Recombinant (His & hFc)
    TMPY-01021
    AXL Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 74.5 kDa and the accession number is Q00993.
    • $600
    7-10 days
    Size
    QTY
  • TIE2 Protein, Human, Recombinant (His & hFc)
    TMPY-00930
    TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1.
    • $386
    In Stock
    Size
    QTY
  • EphB2 Protein, Human, Recombinant (His & hFc)
    TMPY-00784
    EphB2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 86 kDa and the accession number is P29323-2.
    • $600
    7-10 days
    Size
    QTY
  • EphB6 Protein, Human, Recombinant (hFc)
    TMPY-00789
    EphB6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 86.5 kDa and the accession number is O15197.
    • $398
    7-10 days
    Size
    QTY
  • FGFR4 Protein, Human, Recombinant (hFc)
    TMPY-00806
    FGFR4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66 kDa and the accession number is P22455-1.
    • $600
    7-10 days
    Size
    QTY
  • HER3/ERBB3 Protein, Human, Recombinant (hFc)
    TMPY-00795
    HER3/ERBB3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.4 kDa and the accession number is P21860-1.
    • $303
    7-10 days
    Size
    QTY
  • BMPR1A/ALK-3 Protein, Mouse, Recombinant (His & hFc)
    TMPY-00962
    BMPR1A/ALK-3 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 42 kDa and the accession number is P36895.
    • $700
    7-10 days
    Size
    QTY
  • PDGFRA Protein, Human, Recombinant (His)
    TMPY-01139
    PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is P16234-1.
    • $386
    In Stock
    Size
    QTY
  • EphB6 Protein, Human, Recombinant (His)
    TMPY-01424
    EphB6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.6 kDa and the accession number is O15197.
    • $600
    7-10 days
    Size
    QTY
  • DDR1 Protein, Human, Recombinant (His)
    TMPY-01289
    DDR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is A0A024RCQ1.
    • $386
    In Stock
    Size
    QTY
  • ALK-4/ACVR1B Protein, Human, Recombinant (His)
    TMPY-01293
    ALK-4/ACVR1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is P36896-1.
    • $600
    7-10 days
    Size
    QTY
  • EphA4 Protein, Mouse, Recombinant (His)
    TMPY-01778
    EphA4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is Q03137-1.
    • $904
    7-10 days
    Size
    QTY
  • EphA2 Protein, Mouse, Recombinant (His)
    TMPY-01777
    EphA2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58 kDa and the accession number is Q03145.
    • $600
    7-10 days
    Size
    QTY
  • EphB3 Protein, Mouse, Recombinant (His)
    TMPY-01784
    EphB3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57 kDa and the accession number is P54754.
    • $904
    7-10 days
    Size
    QTY
  • DDR1 Protein, Mouse, Recombinant (hFc)
    TMPY-02506
    DDR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71 kDa and the accession number is Q03146-1.
    • $600
    7-10 days
    Size
    QTY
  • HER3/ERBB3 Protein, Rhesus, Recombinant (hFc)
    TMPY-02478
    HER3/ERBB3 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.7 kDa and the accession number is XP_001113953.2.
    • $600
    7-10 days
    Size
    QTY
  • EphA4 Protein, Rhesus, Recombinant (hFc)
    TMPY-02942
    EphA4 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.4kDa and the accession number is A0A8J8XFI3.
    • $600
    7-10 days
    Size
    QTY