Shopping Cart

Your shopping cart is currently empty

Argipressin

Name: Argipressin
Brand: TargetMol
SKU: T7434
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T7434Cas No. 113-79-1

Alias AVP, Arg8-vasopressin

Argipressin (Arg8-vasopressin) inhibits central corticotropin-releasing hormone. Argipressin acts as a repressor in the regulation of central CRH levels. 5A2-SC8 is an APC-dependent protein.

Argipressin

Copy Product Info

😃Good

Catalog No. T7434Alias AVP, Arg8-vasopressinCas No. 113-79-1

Argipressin (Arg8-vasopressin) inhibits central corticotropin-releasing hormone. Argipressin acts as a repressor in the regulation of central CRH levels. 5A2-SC8 is an APC-dependent protein.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	-	In Stock
5 mg	$91	-	In Stock
10 mg	$120	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Argipressin (Arg8-vasopressin) inhibits central corticotropin-releasing hormone. Argipressin acts as a repressor in the regulation of central CRH levels. 5A2-SC8 is an APC-dependent protein.
Targets&IC50	A7r5 cells (rat):1.31 nM (Kd), A7r5 cells (rat):5 nM (EC50)
In vitro	Argipressin exhibits a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells by binding to vasopressin arginine receptor V1. In addition, it stimulated intracellular calcium release in A7r5 cells with an EC50 of 5 nM. [1] Argipressin induces [Ca2+]i signaling in DRG cell cultures and exhibits immunoreactivity against S-100. The lowest effective concentration of Argipressin for inducing [Ca2+]i responses in DRG-cultured non-neuronal cells is 100 pM. [2]
In vivo	In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.
Synonyms	AVP, Arg8-vasopressin

Chemical Properties

Molecular Weight	1084.23
Formula	C₄₆H₆₅N₁₅O₁₂S₂
Cas No.	113-79-1
Smiles	C(=O)(N1[C@H](C(N[C@H](C(NCC(N)=O)=O)CCCNC(=N)N)=O)CCC1)[C@H]2NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@@H](N)CSSC2
Relative Density.	1.59 g/cm3 (Predicted)
Sequence	Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6)
Sequence Short	CYFQNCPRG (Disulfide bridge: Cys1-Cys6)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (73.79 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.9223 mL	4.6116 mL	9.2231 mL	46.1157 mL
5 mM	0.1845 mL	0.9223 mL	1.8446 mL	9.2231 mL
10 mM	0.0922 mL	0.4612 mL	0.9223 mL	4.6116 mL
20 mM	0.0461 mL	0.2306 mL	0.4612 mL	2.3058 mL
50 mM	0.0184 mL	0.0922 mL	0.1845 mL	0.9223 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc