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Insulin sensitizer C59
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Catalog No. T87943Cas No. 2761446-81-3
Insulin sensitizer C59 is an orally available insulin sensitizer that improves glucose uptake and can be used to study insulin-stimulated GLUT4 translocation.
Insulin sensitizer C59
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Purity: 99.98%
Catalog No. T87943Cas No. 2761446-81-3
Insulin sensitizer C59 is an orally available insulin sensitizer that improves glucose uptake and can be used to study insulin-stimulated GLUT4 translocation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | - | In Stock | |
| 5 mg | $48 | - | In Stock | |
| 10 mg | $78 | - | In Stock | |
| 25 mg | $159 | - | In Stock | |
| 50 mg | $259 | - | In Stock | |
| 100 mg | $413 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Insulin sensitizer C59 is an orally available insulin sensitizer that improves glucose uptake and can be used to study insulin-stimulated GLUT4 translocation. |
| In vivo | Lean mice were injected with either vehicle or Insulin sensitizer C59 before performing IPGTT. Like C3, Insulin sensitizer C59 injection resulted in improved glucose tolerance compared to vehicle. Oral administration of Insulin sensitizer C59 to DIO mice by providing them with HFD supplemented with Insulin sensitizer C59 for 2 weeks also resulted in significantly improved glucose tolerance, thus demonstrating oral availability of the compound. Injection of Insulin sensitizer C59 did not result in a lower body weight compared to control, suggesting that the improved glucose tolerance is not due to decreased weight gain. [1] |
| Molecular Weight | 325.23 |
| Formula | C16H18Cl2N2O |
| Cas No. | 2761446-81-3 |
| Smiles | O=C(NC1=NC=C(Cl)C(Cl)=C1)C23CC4CC(CC(C4)C2)C3 |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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