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L-Thyroxine sodium salt pentahydrate

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Catalog No. T15699Cas No. 6106-07-6
Alias Sodium levothyroxine pentahydrate

L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine pentahydrate) is a thyroid hormone with anticholesterol activity that inhibits the release of thyroid hormones from thyroid cancer nodules and is used in immune and endocrine disorders such as hypothyroidism, myxedema, cretinism and obesity. diseases, such as hypothyroidism, myxedema, cretinism and obesity.

L-Thyroxine sodium salt pentahydrate
Other Forms of L-Thyroxine sodium salt pentahydrate:

L-Thyroxine sodium salt pentahydrate

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Purity: 99.84%
Catalog No. T15699Alias Sodium levothyroxine pentahydrateCas No. 6106-07-6
L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine pentahydrate) is a thyroid hormone with anticholesterol activity that inhibits the release of thyroid hormones from thyroid cancer nodules and is used in immune and endocrine disorders such as hypothyroidism, myxedema, cretinism and obesity. diseases, such as hypothyroidism, myxedema, cretinism and obesity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 mg$30-In Stock
1 mL x 10 mM (in DMSO)$50-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.84%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine pentahydrate) is a thyroid hormone with anticholesterol activity that inhibits the release of thyroid hormones from thyroid cancer nodules and is used in immune and endocrine disorders such as hypothyroidism, myxedema, cretinism and obesity. diseases, such as hypothyroidism, myxedema, cretinism and obesity.
In vivo
In experimental rats fed a 12-week iodine-free diet, levels of triiodothyronine and L-thyroxine were significantly decreased compared to controls on a standard diet. In the low-dose L-Thyroxine sodium salt pentahydrate-treated group, an increase in L-thyroxine levels was observed, while triiodothyronine levels were virtually indistinguishable from those of the control group. Rats receiving high-dose L-Thyroxine sodium salt pentahydrate treatment had significantly increased circulating concentrations of triiodothyronine and L-thyroxine compared to the untreated hypothyroid group, and L-thyroxine levels were significantly increased compared to the control group. [2]
SynonymsSodium levothyroxine pentahydrate
Chemical Properties
Molecular Weight888.93
FormulaC15H20I4NNaO9
Cas No.6106-07-6
SmilesIC(C=C1OC2=C(C=C(C=C2I)C[C@H](N)C([O-])=O)I)=C(C(I)=C1)O.[Na+].O.O.O.O.O
Relative Density.2.381 g/cm3
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 0.1 mg/mL (insoluble)
DMSO: 20 mg/mL (22.5 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.25 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1249 mL5.6247 mL11.2495 mL56.2474 mL
5 mM0.2250 mL1.1249 mL2.2499 mL11.2495 mL
10 mM0.1125 mL0.5625 mL1.1249 mL5.6247 mL
20 mM0.0562 mL0.2812 mL0.5625 mL2.8124 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Thyroidhormonereceptor(THR)ThyroidhormonereceptorThyroid hormone receptor(THR)Thyroid hormone receptorTHRSodium levothyroxineMetabolismLThyroxine sodium salt pentahydrateL-Thyroxine sodium saltL-Thyroxine sodium PentahydrateL-Thyroxine sodiumLevothyroxine sodium salt pentahydrateL Thyroxine sodium salt pentahydrate
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