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CGP 20712 A

Name: CGP 20712 A
Brand: TargetMol
SKU: T10778
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10778Cas No. 105737-62-0

Alias CGP 20712 mesylate

CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.

CGP 20712 A

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Purity: 99.37%

Catalog No. T10778Alias CGP 20712 mesylateCas No. 105737-62-0

CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$428	In Stock	In Stock
25 mg	$698	In Stock	In Stock
50 mg	$968	In Stock	In Stock
100 mg	$1,280	In Stock	In Stock
200 mg	$1,760	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.37%

Appearance:Solid

Color:Yellow

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.
Targets&IC50	β1-adrenoceptor:0.7 nM , β1-adrenoceptor:0.7 nM
In vitro	In myocyte, saturation experiments conducted in the presence of 300nM CGP 20712A failed to detect specific binding of [125I]-ICYP and [3H]-CGP 12177[2].
In vivo	Pre-treatment with 5mg/kg CGP 20712A (selective β1-adrenoceptor antagonist) in 8-day-old rats did not alter the plasma ACTH response to insulin injection[3].
Synonyms	CGP 20712 mesylate

Chemical Properties

Molecular Weight	590.57
Formula	C₂₄H₂₉F₃N₄O₈S
Cas No.	105737-62-0
Smiles	O=C(N)C1=CC(OCCNCC(O)COC=2C=CC(=CC2)C3=NC(=CN3C)C(F)(F)F)=CC=C1O.O=S(=O)(O)C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (135.46 mM), Sonification is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6933 mL	8.4664 mL	16.9328 mL	84.6640 mL
5 mM	0.3387 mL	1.6933 mL	3.3866 mL	16.9328 mL
10 mM	0.1693 mL	0.8466 mL	1.6933 mL	8.4664 mL
20 mM	0.0847 mL	0.4233 mL	0.8466 mL	4.2332 mL
50 mM	0.0339 mL	0.1693 mL	0.3387 mL	1.6933 mL
100 mM	0.0169 mL	0.0847 mL	0.1693 mL	0.8466 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc