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CGP 20712 A

Name: CGP 20712 A
Brand: TargetMol
SKU: T10778
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10778Cas No. 105737-62-0

Alias CGP 20712 mesylate

CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.

CGP 20712 A

🥰Excellent

Purity: 99.37%

Catalog No. T10778Alias CGP 20712 mesylateCas No. 105737-62-0

CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.

Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$289	In Stock
10 mg	$428	In Stock
25 mg	$698	In Stock
50 mg	$968	In Stock
100 mg	$1,280	In Stock
200 mg	$1,760	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.37%

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COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.
Targets&IC50	β1-adrenoceptor:0.7 nM, β1-adrenoceptor:0.7 nM
In vitro	In myocyte, saturation experiments conducted in the presence of 300nM CGP 20712A failed to detect specific binding of [125I]-ICYP and [3H]-CGP 12177[2].
In vivo	Pre-treatment with 5mg/kg CGP 20712A (selective β1-adrenoceptor antagonist) in 8-day-old rats did not alter the plasma ACTH response to insulin injection[3].
Synonyms	CGP 20712 mesylate

Chemical Properties

Molecular Weight	590.57
Formula	C₂₄H₂₉F₃N₄O₈S
Cas No.	105737-62-0
Smiles	O=C(N)C1=CC(OCCNCC(O)COC=2C=CC(=CC2)C3=NC(=CN3C)C(F)(F)F)=CC=C1O.O=S(=O)(O)C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (135.46 mM), Sonification is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6933 mL	8.4664 mL	16.9328 mL	84.6640 mL
5 mM	0.3387 mL	1.6933 mL	3.3866 mL	16.9328 mL
10 mM	0.1693 mL	0.8466 mL	1.6933 mL	8.4664 mL
20 mM	0.0847 mL	0.4233 mL	0.8466 mL	4.2332 mL
50 mM	0.0339 mL	0.1693 mL	0.3387 mL	1.6933 mL
100 mM	0.0169 mL	0.0847 mL	0.1693 mL	0.8466 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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