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Meglutol

🥰Excellent
Catalog No. T1664Cas No. 503-49-1
Alias Dicrotalic acid, 3-Hydroxy-3-methylglutaric acid

Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethyl glutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate-limiting enzyme in the biosynthesis of cholesterol.

Meglutol

Meglutol

🥰Excellent
Purity: 99.94%
Catalog No. T1664Alias Dicrotalic acid, 3-Hydroxy-3-methylglutaric acidCas No. 503-49-1
Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethyl glutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate-limiting enzyme in the biosynthesis of cholesterol.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$45In StockIn Stock
100 mg$74In StockIn Stock
1 mL x 10 mM (in DMSO)$48In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.94%
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Product Introduction

Bioactivity
Description
Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethyl glutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate-limiting enzyme in the biosynthesis of cholesterol.
SynonymsDicrotalic acid, 3-Hydroxy-3-methylglutaric acid
Chemical Properties
Molecular Weight162.14
FormulaC6H10O5
Cas No.503-49-1
SmilesCC(O)(CC(O)=O)CC(O)=O
Relative Density.1.417 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 100 mg/mL (616.7 mM), Sonication is recommended.
DMSO: 65 mg/mL (400.89 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.34 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM6.1675 mL30.8375 mL61.6751 mL308.3755 mL
5 mM1.2335 mL6.1675 mL12.3350 mL61.6751 mL
10 mM0.6168 mL3.0838 mL6.1675 mL30.8375 mL
20 mM0.3084 mL1.5419 mL3.0838 mL15.4188 mL
50 mM0.1234 mL0.6168 mL1.2335 mL6.1675 mL
100 mM0.0617 mL0.3084 mL0.6168 mL3.0838 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MeglutolInhibitorinhibitHMGCRHMGCoAReductaseHMG-CoA Reductase (HMGCR)HMG-CoA reductaseHMGCoA ReductaseEndogenousMetaboliteEndogenous MetaboliteAutophagy
Related Tags: buy Meglutol | purchase Meglutol | Meglutol cost | order Meglutol | Meglutol chemical structure | Meglutol formula | Meglutol molecular weight
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