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MB-311
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Catalog No. T9901A-1267
MB-311 is a fully humanized monoclonal antibody targeting the tumor-associated antigen Lewis Y (LeY), acting by specifically binding to the LeY carbohydrate structures on the surface of tumor cells. The compound is an essential tool for investigating immunotherapy mechanisms against carbohydrate antigens, aiming to achieve precise clearance of tumor cells by inducing robust antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).
MB-311
MB-311
Copy Product Info🥰Excellent
Catalog No. T9901A-1267
MB-311 is a fully humanized monoclonal antibody targeting the tumor-associated antigen Lewis Y (LeY), acting by specifically binding to the LeY carbohydrate structures on the surface of tumor cells. The compound is an essential tool for investigating immunotherapy mechanisms against carbohydrate antigens, aiming to achieve precise clearance of tumor cells by inducing robust antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).
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Product Introduction
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Related Conjugates and Formulations
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Chemical Properties
Antibody Information
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| Description | MB-311 is a fully humanized monoclonal antibody targeting the tumor-associated antigen Lewis Y (LeY), acting by specifically binding to the LeY carbohydrate structures on the surface of tumor cells. The compound is an essential tool for investigating immunotherapy mechanisms against carbohydrate antigens, aiming to achieve precise clearance of tumor cells by inducing robust antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). |
| In vitro | In human Lewis Y-expressing tumor cell lines, MB-311 induced potent ADCC and stimulated the release of TNF-alpha and IFN-gamma [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | Lewis Y |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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