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Anti-CAV1 Antibody (8N14)
😃Good
Catalog No. TMAH-00147
Alias VIP21, VIP 21, PPH3, OTTHUMP00000025031, MSTP085, LCCNS, CGL3, cell growth-inhibiting protein 32, Caveolin-1, Caveolin1, Caveolin 1 caveolae protein 22kDa, caveolin 1 beta isoform, caveolin 1 alpha isoform, caveolae protein, 22 kD, CAV 1, CAV, BSCL3
Anti-CAV1 Antibody (8N14) is an antibody targeting CAV1. Anti-CAV1 Antibody (8N14) can be used in ELISA, WB, FCM.
Anti-CAV1 Antibody (8N14)
Anti-CAV1 Antibody (8N14)
😃Good
Catalog No. TMAH-00147Alias VIP21, VIP 21, PPH3, OTTHUMP00000025031, MSTP085, LCCNS, CGL3, cell growth-inhibiting protein 32, Caveolin-1, Caveolin1, Caveolin 1 caveolae protein 22kDa, caveolin 1 beta isoform, caveolin 1 alpha isoform, caveolae protein, 22 kD, CAV 1, CAV, BSCL3
Anti-CAV1 Antibody (8N14) is an antibody targeting CAV1. Anti-CAV1 Antibody (8N14) can be used in ELISA, WB, FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Mouse Monoclonal Application: ELISA, WB, FCM Reactivity: Human, Mouse, Rat |
| Alias | VIP21, VIP 21, PPH3, OTTHUMP00000025031, MSTP085, LCCNS, CGL3, cell growth-inhibiting protein 32, Caveolin-1, Caveolin1, Caveolin 1 caveolae protein 22kDa, caveolin 1 beta isoform, caveolin 1 alpha isoform, caveolae protein, 22 kD, CAV 1, CAV, BSCL3 |
| Ig Type | mIgG2a |
| Clone | 8N14 |
| Reactivity | Human, Mouse, Rat |
| Verified Activity | 1. Western Blot -Positive WB detected in:PC-3 whole cell lysate (20µg), A549 whole cell lysate (20µg), U251 whole cell lysate (20µg), Hela whole cell lysate (20µg), MCF-7 whole cell lysate (20µg), HEK293 whole cell lysate (20µg), Mouse Heart tissue lysate (20µg), Rat Heart tissue lysate (20µg) -All lanes: CAV1 antibody at 1:500 -Secondary: Goat polyclonal to mouse IgG at 1/50000 dilution -Predicted band size:20 kDa -Observed band size:20 kDa -Exposure time:120s 2. Overlay Peak curve showing Hela cells stained with TMAH-00147 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was mouse IgG (1ug/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | ELISA, WB, FCM |
| Recommended Dose | WB:1:500-1:2000; FCM:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CAV1 Protein |
| Antigen Species | Human |
| Gene ID | 857 |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Tags & Cell Markers, Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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