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Anti-Fibronectin Antibody (6C224)
(Synonyms: FN1, Fibronectin) Copy Product Info
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Synonyms: FN1, Fibronectin
Catalog No. TMAH-00446 Copy Product Info
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Anti-Fibronectin Antibody (6C224) is an antibody targeting Fibronectin. Anti-Fibronectin Antibody (6C224) can be used in ELISA,FCM.
Anti-Fibronectin Antibody
(6C224)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $207 | 7-10 days | 7-10 days | |
| 100 µL | $347 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-Fibronectin Antibody (6C224) is an antibody targeting Fibronectin. Anti-Fibronectin Antibody (6C224) can be used in ELISA,FCM. |
| Synonyms | FN1, Fibronectin |
| Ig Type | Rabbit IgG |
| Clone | 6C224 |
| Reactivity | Human |
| Verified Activity | Overlay Peak curve showing 3T3 cells stained with TMAH-00446 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | |
| Recommended Dose | FCM:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix. |
| Tissue Specificity | Expressed in the inner limiting membrane and around blood vessels in the retina (at protein level). Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and ot |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human FN1 |
| Antigen Species | Human |
| Gene Name | FN1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Developmental biology, Signal transduction, Stem cells |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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