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Anti-OTUB2 Antibody (4V813)

😃Good
Catalog No. TMAY-02522
Alias OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2, OTB2, C14orf137

Anti-OTUB2 Antibody (4V813) is a Rabbit antibody targeting OTUB2. Anti-OTUB2 Antibody (4V813) can be used in ELISA,ICC/IF.

Anti-OTUB2 Antibody (4V813)

Anti-OTUB2 Antibody (4V813)

😃Good
Catalog No. TMAY-02522Alias OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2, OTB2, C14orf137
Anti-OTUB2 Antibody (4V813) is a Rabbit antibody targeting OTUB2. Anti-OTUB2 Antibody (4V813) can be used in ELISA,ICC/IF.
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100 μL$269 7-10 days
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Product Introduction

Bioactivity
Description
Anti-OTUB2 Antibody (4V813) is a Rabbit antibody targeting OTUB2. Anti-OTUB2 Antibody (4V813) can be used in ELISA,ICC/IF.
AliasOTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2, OTB2, C14orf137
Ig Type
Monoclonal Rabbit IgG
Clone
4V813
Reactivity
Human
Verified Activity
Immunofluorescence staining of Human OTUB2 in A549 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human OTUB2 monoclonal antibody (1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 549-conjugated Goat Anti-rabbit IgG secondary antibody (red). Positive staining was localized to cytoplasm and nucleus.
Application
ELISA,ICC/IF
Recommended Dose
ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human OTUB2 (rh OTUB2; TMPY-02522; Q96DC9-1; Met1-His234).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundOtubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human OTUB2 Protein (TMPY-02522)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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