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Cyasterone

Name: Cyasterone
Brand: TargetMol
SKU: T3870
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3870Cas No. 17086-76-9

Alias Cyasteron

Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity.

Cyasterone

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Purity: 99.70%

Catalog No. T3870Alias CyasteronCas No. 17086-76-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$213	In Stock	In Stock
50 mg	$319	In Stock	In Stock
100 mg	$475	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.70%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Cyasterone AI Summary

Cyasterone demonstrates multifaceted bioactivity, including inhibition of carcinogenesis in mouse models and suppression of EBV-early antigen activation in human Raji cells, exhibiting varying levels of cytotoxicity against these cells at different molar ratios. It also shows a binding affinity to the ecdysone receptor ligand binding domain in Drosophila melanogaster, with an IC50 value of 61.66 nM, as assessed by the number of hydrogen bonds formed. Additionally, Cyasterone acts as an inhibitor of the human ABCB1 pump in mouse L5178 cells, reducing the pump's fluorescence activity ratio to 0.75 at 20 µM for 10 minutes. Furthermore, it inhibits cell proliferation in MTT assays at compound-doxorubicin ratios of 40.8:1 after 48 hours, achieving inhibition levels of 50%, 75%, and 95%, with corresponding FICI values of 1.54, 0.85, and 0.47, indicating its potential utility as an ABCB1 inhibitor in cancer treatment..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity.
Synonyms	Cyasteron

Chemical Properties

Molecular Weight	520.65
Formula	C₂₉H₄₄O₈
Cas No.	17086-76-9
Smiles	C[C@H]1[C@H](C[C@@H](O)[C@](C)(O)[C@H]2CCC3(O)C4=CC(=O)[C@@H]5C[C@@H](O)[C@@H](O)C[C@]5(C)[C@H]4CC[C@]23C)[C@@H](O)COC1=O
Relative Density.	1.31 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (480.17 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9207 mL	9.6034 mL	19.2068 mL	96.0338 mL
5 mM	0.3841 mL	1.9207 mL	3.8414 mL	19.2068 mL
10 mM	0.1921 mL	0.9603 mL	1.9207 mL	9.6034 mL
20 mM	0.0960 mL	0.4802 mL	0.9603 mL	4.8017 mL
50 mM	0.0384 mL	0.1921 mL	0.3841 mL	1.9207 mL
100 mM	0.0192 mL	0.0960 mL	0.1921 mL	0.9603 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc