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Mesutoclax

Name: Mesutoclax
Brand: TargetMol
SKU: T211322
Price: 497 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: ICP-248, ICP248, ICP 248) Copy Product Info

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Synonyms: ICP-248, ICP248, ICP 248

Catalog No. T211322 Copy Product Info

Purity: 98.96%

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Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM, demonstrating weak activity against BCL-XL (IC50: >1000 nM). Mesutoclax (ICP-248) (Compound 5) inhibits the viability of RS4;11 cells with an IC50 of 2.75 nM and is therefore used in apoptosis and cancer cell biology research systems to investigate BCL-2–mediated survival signaling, intrinsic apoptotic pathway activation, and leukemia cell viability regulation.

Cas No. 2760536-87-4

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Pack Size	Price	USA Stock	Global Stock
1 mg	$198	-	In Stock
5 mg	$497	-	In Stock
10 mg	Inquiry	-	In Stock
25 mg	Inquiry	-	In Stock
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.96%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM, demonstrating weak activity against BCL-XL (IC50: >1000 nM). Mesutoclax (ICP-248) (Compound 5) inhibits the viability of RS4;11 cells with an IC50 of 2.75 nM and is therefore used in apoptosis and cancer cell biology research systems to investigate BCL-2–mediated survival signaling, intrinsic apoptotic pathway activation, and leukemia cell viability regulation.
Targets & IC50	RS4;11 cells:2.75 nM, BCL-2:1.54 nM
Synonyms	ICP-248, ICP248, ICP 248

Chemical Properties

Molecular Weight	884.44
Formula	C₄₅H₅₀ClN₇O₈S
Cas No.	2760536-87-4
Smiles	CC(C)(CC1)CC(C2=CC=C(C=C2)Cl)=C1CN3[C@@H](CN(C4=CC(OC5=CN=C(NC=C6)C6=C5)=C(C=C4)C(NS(=O)(C7=CC([N+]([O-])=O)=C(C=C7)NC[C@H]8COCCO8)=O)=O)CC3)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (90.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1307 mL	5.6533 mL	11.3066 mL	56.5329 mL
5 mM	0.2261 mL	1.1307 mL	2.2613 mL	11.3066 mL
10 mM	0.1131 mL	0.5653 mL	1.1307 mL	5.6533 mL
20 mM	0.0565 mL	0.2827 mL	0.5653 mL	2.8266 mL
50 mM	0.0226 mL	0.1131 mL	0.2261 mL	1.1307 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Mesutoclax chemical structure | Mesutoclax formula | Mesutoclax molecular weight