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Lu AA33810 (Synonyms: LuAA33810, Lu AA-33810)

Name: Lu AA33810
Brand: TargetMol
SKU: T22935
Price: 109 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T22935 Copy Product Info

Purity: 99.61%

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Lu AA33810 is a selective neuropeptide Y5 (NPY5) receptor antagonist with an oral activity and blood-brain barrier permeability advantage, exhibiting anti-anxiety and antidepressant-like effects at a Ki = 1.5 nM for rat receptors.

Lu AA33810

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Catalog No. T22935

Synonyms LuAA33810, Lu AA-33810

Cas No. 304008-29-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$109	-	In Stock
5 mg	$278	-	In Stock
10 mg	$448	-	In Stock
25 mg	$728	-	In Stock
50 mg	$982	-	In Stock
100 mg	$1,350	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.61%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lu AA33810 is a selective neuropeptide Y5 (NPY5) receptor antagonist with an oral activity and blood-brain barrier permeability advantage, exhibiting anti-anxiety and antidepressant-like effects at a Ki = 1.5 nM for rat receptors.
Targets&IC50	Y5 receptor (human):1.5 nM (Ki)
In vivo	Lu AA33810 (3-30 mg/kg, oral administration) showed anxiolytic-like effects in SD rats tested with the social interaction test [1]. Lu AA33810 (10 mg/kg/day, intraperitoneal injection) exhibited anxiolytic-like effects in the social interaction test of Flinders Sensitive Line rats and demonstrated antidepressant-like effects in the forced swim test [1]. Lu AA33810 (3 and 10 mg/kg/day, intraperitoneal injection) produced antidepressant-like activity in Wistar rats subjected to chronic mild stress, restoring the stress-induced decrease in sucrose consumption [1].
Synonyms	LuAA33810, Lu AA-33810

Chemical Properties

Molecular Weight	423.62
Formula	C₁₉H₂₅N₃O₂S₃
Cas No.	304008-29-5
Smiles	N(C1=NC=2C=3C(SCCC2S1)=CC=CC3)[C@@H]4CC[C@@H](CNS(C)(=O)=O)CC4
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (75.54 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3606 mL	11.8030 mL	23.6061 mL	118.0303 mL
5 mM	0.4721 mL	2.3606 mL	4.7212 mL	23.6061 mL
10 mM	0.2361 mL	1.1803 mL	2.3606 mL	11.8030 mL
20 mM	0.1180 mL	0.5902 mL	1.1803 mL	5.9015 mL
50 mM	0.0472 mL	0.2361 mL	0.4721 mL	2.3606 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc