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PTX3 Protein, Mouse, Recombinant (His)

Catalog No. TMPJ-00981
Synonyms: alpha-induced protein 5, pentraxin 3, long, pentaxin-related gene, rapidly induced by IL-1 β, tumor necrosis factor, Pentaxin-related protein PTX3, pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, pentraxin-related gene, rapidly induced by IL-1 beta, Pentraxin 3, pentraxin-3, pentraxin-related gene, rapidly induced by IL-1 β, pentraxin-related protei, α-induced protein 5

Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.

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PTX3 Protein, Mouse, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 184.00
50 μg 5 days $ 545.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,970.00
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Biological Description
Technical Params
Product Properties
Description Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.
Species Mouse
Expression System Human Cells
Tag N-6His
Accession Number P48759
Synonyms alpha-induced protein 5, pentraxin 3, long, pentaxin-related gene, rapidly induced by IL-1 β, tumor necrosis factor, Pentaxin-related protein PTX3, pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, pentraxin-related gene, rapidly induced by IL-1 beta, Pentraxin 3, pentraxin-3, pentraxin-related gene, rapidly induced by IL-1 β, pentraxin-related protei, α-induced protein 5
Amino Acid Glu18-Ser381
Construction Recombinant Mouse Pentraxin-related protein PTX3 is produced by our Mammalian expression system and the target gene encoding Glu18-Ser381 is expressed with a 6His tag at the N-terminus.
Protein Purity Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 54 KDa, reducing conditions
Endotoxin Less than 1 EU/µg as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Research Background Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.

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Keywords

PTX3 Protein, Mouse, Recombinant (His) alpha-induced protein 5 pentraxin 3, long pentaxin-related gene, rapidly induced by IL-1 β, tumor necrosis factor Pentaxin-related protein PTX3 pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor pentraxin-related gene, rapidly induced by IL-1 beta Pentraxin 3 pentraxin-3 pentraxin-related gene, rapidly induced by IL-1 β a-induced protein 5 pentraxin-related protei α-induced protein 5 recombinant recombinant-proteins proteins protein

 

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