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Lipid

The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK2 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplas

  • Lifibrol
    T2783296609-16-4In house
    Lifibrol (U-83860) is an inhibitor of cholesterol synthesis.Lifibrol has anticholesterol and hypolipidemic properties and promotes the conversion of LDL Apo B-100 in patients with hypercholesterolemia and mixed hyperlipidemia.
    • $146
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  • VK-28
    T9956312611-92-0
    VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.
    • $195
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  • Carboxylesterase-IN-3
    T607882764748-92-5In house
    Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.
    • $98
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  • MSU-42011
    T774992456434-36-7In house
    MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and p-ERK at the protein level.MSU-42011 has demonstrated antitumor activity in a kras-driven mouse model of lung cancer.MSU-42011 is an effective therapy for the treatment of preclinical krasdriven lung cancer and has immunomodulatory activity.
    • $41
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  • Fatostatin
    T9266125256-00-0
    Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.
    • $30
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    TargetMol | Citations Cited
  • Betulin
    T3121473-98-3
    Betulin (betulinol) (lup-20(29)-ene-3β, 28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees where it forms up to 30% of the dry weight of the extractive and is found in birch sap as well.
    • $50
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    TargetMol | Citations Cited
  • PF 429242
    T4317947303-87-9
    PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO c
    • $37
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    TargetMol | Citations Cited
  • Icariside E4
    TN5431126253-42-7
    Icariside E4 is a natural compound derived from Ulmus minor that acts via AMPK phosphorylation and inhibition of MID1IP2 hypolipidation in HepG1 cells.Icariside E4 has anti-injurious, antioxidant, anti-Alzheimer's and anti-inflammatory effects and inhibits SREBP-1c, liver X receptor-α (LXR) and FASN in Icariside E4 is an effective candidate for the treatment of fatty liver disease and has hypolipidemic potential in HepG1 cells.
    • $1,620
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  • Isolicoflavonol
    TN178394805-83-1
    Isolicoflavonol is a potential cancer chemopreventive agent.
    • $898
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  • Fenipentol
    T0857583-03-9
    Fenipentol (Pancoral) has the properties of Choleretics and Cholagogues.
    • $30
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  • Carboxylesterase-IN-2
    T775242764748-88-9
    Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.
    • $97
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  • MAGL-IN-5
    T9967359714-55-9
    MAGL-IN-5 is a non-selective lipase inhibitor.
    • $39
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  • Ethyl phenylglyoxylate
    T203511603-79-8
    Ethyl phenylglyoxylate (AI3 10033) is a simultaneous inhibitor and substrate of chicken liver carboxylesterase.
    • $29
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  • Mevastatin
    T068373573-88-3
    Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
    • $51
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  • Probucol
    T025423288-49-5
    Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
    • $58
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  • Atractylodin
    T366655290-63-6
    Atractylodin (Atractydin) has high lipase inhibitory activity (IC5:39.12 μM); Atractylodin possesses strong repellency activities against T. castaneum adults (LD50: 1.83 μg/cm). The repellency of Atractylodin (0.63 μg/cm) can achieve >90%.
    • $39
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  • Dehydrocholate sodium
    T0516145-41-5
    Dehydrocholate sodium, a hydrocholeretic, can increase bile output to clear increased bile acid load.
    • $42
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  • Cetilistat
    T3283282526-98-1
    Cetilistat (ATL-962) is a novel inhibitor of pancreatic lipase being developed by Alizyme for the treatment of obesity and associated co-morbidities, including type 2 diabetes.
    • $37
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