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Tyrphostin A9
😃Good
Catalog No. T2479Cas No. 10537-47-0
Alias Tyrphostin 9, SF 6847, RG-50872, Malonoben, AG 17
Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor
Tyrphostin A9
😃Good
Purity: 99.87%
Catalog No. T2479Alias Tyrphostin 9, SF 6847, RG-50872, Malonoben, AG 17Cas No. 10537-47-0
Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $38 | In Stock | In Stock | |
| 50 mg | $53 | In Stock | In Stock | |
| 100 mg | $93 | In Stock | In Stock | |
| 500 mg | $283 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.87%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor |
| Targets&IC50 | EGFR:460 μM, PDGFR:0.5 μM |
| In vivo | SF 6847 prevents the PDGF-induced tyrosine phosphorylation of LGF in caveolae of human fibroblasts, suggesting that PDGF-BB-mediated activation of LRP requires tyrosine phosphorylation and thereby activates PDGFR-β. Additionally, SF 6847 inhibits the replication of Herpes Simplex Virus Type 1 (HSV-1) with an IC50 of 40 nM and enhances the inclusion of MAPT exon 10 in SHSY-5Y cells by twofold at a concentration of 1.6 μM. At 1 mM, it blocks the strain-induced stimulation of DNA synthesis in fetal lung cells. SF 6847 partially reverses vanadate-induced HSV-1 plaque formation at 50 nM and reduces viral phosphoprotein phosphorylation in a dose-dependent manner at concentrations below 400 nM. However, the reduction in protein synthesis induced by SF 6847 at concentrations below 800 nM is not dose-dependent. |
| Synonyms | Tyrphostin 9, SF 6847, RG-50872, Malonoben, AG 17 |
| Molecular Weight | 282.38 |
| Formula | C18H22N2O |
| Cas No. | 10537-47-0 |
| Smiles | CC(C)(C)c1cc(C=C(C#N)C#N)cc(c1O)C(C)(C)C |
| Relative Density. | 1.064 g/cm3 |
| Storage | store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (885.33 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.08 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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