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HDAC6/8/BRPF1-IN-1

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Catalog No. T61727Cas No. 2484255-65-2

HDAC6/8/BRPF1-IN-1 is a dual inhibitor targeting HDAC6, HDAC8, and the bromodomain and PHD finger containing protein 1 (BRPF1). It exhibits inhibitory activity against HDAC1, HDAC6, and HDAC8 with IC50 values of 797 nM, 344 nM, and 908 nM, respectively, and inhibits BRPF1 with a Kd value of 175.2 nM. This compound is utilized in cancer research [1].

HDAC6/8/BRPF1-IN-1

HDAC6/8/BRPF1-IN-1

😃Good
Catalog No. T61727Cas No. 2484255-65-2
HDAC6/8/BRPF1-IN-1 is a dual inhibitor targeting HDAC6, HDAC8, and the bromodomain and PHD finger containing protein 1 (BRPF1). It exhibits inhibitory activity against HDAC1, HDAC6, and HDAC8 with IC50 values of 797 nM, 344 nM, and 908 nM, respectively, and inhibits BRPF1 with a Kd value of 175.2 nM. This compound is utilized in cancer research [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
HDAC6/8/BRPF1-IN-1 is a dual inhibitor targeting HDAC6, HDAC8, and the bromodomain and PHD finger containing protein 1 (BRPF1). It exhibits inhibitory activity against HDAC1, HDAC6, and HDAC8 with IC50 values of 797 nM, 344 nM, and 908 nM, respectively, and inhibits BRPF1 with a Kd value of 175.2 nM. This compound is utilized in cancer research [1].
Targets&IC50
HDAC8:908 nM, HDAC6:344 nM, HDAC1:797 nM
In vitro
HDAC6/8/BRPF1-IN-1 exhibits inhibitory activity against HDAC1, HDAC6, and HDAC8, with IC50 values of 797 nM, 344 nM, and 908 nM, respectively, and demonstrates inhibition of BRPF1 with a Kd value of 175.2 nM [1].
Chemical Properties
Molecular Weight387.41
FormulaC18H17N3O5S
Cas No.2484255-65-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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