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Endosidin 7
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Catalog No. T69436Cas No. 329072-88-0
Alias Endosidin-7
Endosidin 7, a specific inhibitor of callose synthase, organizes callose deposition during plant cytoplasmic division without affecting endosomal transport during interphase or cytoskeletal organization, preventing late cytokinesis.
Endosidin 7
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Purity: 99.65%
Catalog No. T69436Alias Endosidin-7Cas No. 329072-88-0
Endosidin 7, a specific inhibitor of callose synthase, organizes callose deposition during plant cytoplasmic division without affecting endosomal transport during interphase or cytoskeletal organization, preventing late cytokinesis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | In Stock | In Stock | |
| 5 mg | $722 | In Stock | In Stock | |
| 10 mg | $987 | In Stock | In Stock | |
| 25 mg | $1,520 | In Stock | In Stock | |
| 50 mg | $1,980 | In Stock | In Stock | |
| 100 mg | $2,500 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.65%
Appearance:Solid
Color:Yellow
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Endosidin 7, a specific inhibitor of callose synthase, organizes callose deposition during plant cytoplasmic division without affecting endosomal transport during interphase or cytoskeletal organization, preventing late cytokinesis. |
| Targets&IC50 | callose synthase (Arabidopsis, CHAPS-extracted membranes):100 μM |
| In vitro | Endosidin 7 (ES7) inhibits Arabidopsis callose synthase activity in a concentration-dependent manner using CHAPS-extracted membrane fractions. At 100 μM, ES7 reduces enzyme activity by approximately 50%. Enzyme kinetics indicate that ES7 acts as a mixed-type inhibitor, increasing the apparent Km and decreasing the Vmax, suggesting interaction with both the free enzyme and the enzyme–substrate complex at different affinities[1]. |
| In vivo | Endosidin 7 effectively arrests late cytokinesis in Arabidopsis seedlings. Root growth assays determined an IC₅₀ of 4.8 μM. A 2-hour treatment with 25–50 μM Endosidin 7 induces cell plate fragmentation, binucleate cells, and complete inhibition of callose deposition at the cell plate. Endosidin 7 specifically targets late cytokinesis without affecting interphase endomembrane markers or cellulose biosynthesis[1]. |
| Synonyms | Endosidin-7 |
| Molecular Weight | 467.94 |
| Formula | C26H26ClNO5 |
| Cas No. | 329072-88-0 |
| Smiles | O=C(OC)C1=C(NC2=C(C(=O)CC(C3=CC=C(Cl)C=C3)C2)C1C=4C=CC=C(OC)C4OC)C |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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