Ferroptosis-IN-8

Name: Ferroptosis-IN-8
Brand: TargetMol
SKU: T206031
Rating: 4.5 (1 reviews)

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Catalog No. T206031Cas No. 3056016-82-8

Alias Ferroptosis IN8

Ferroptosis-IN-8 (Compound B4) is a potent and specific small molecule inhibitor of ferroptosis, demonstrating a half-maximal inhibitory concentration (IC50) of 40.49 nM. it suppresses RSL3- or FIN56-induced ferroptosis through robust antioxidant mechanisms, alleviates models of hepatorenal injury, and shows significant potential in preventing a spectrum of ferroptosis-related diseases.

Ferroptosis-IN-8

🥰Excellent

Catalog No. T206031Alias Ferroptosis IN8Cas No. 3056016-82-8

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Product Introduction

Bioactivity

Description	Ferroptosis-IN-8 (Compound B4) is a potent and specific small molecule inhibitor of ferroptosis, demonstrating a half-maximal inhibitory concentration (IC50) of 40.49 nM. it suppresses RSL3- or FIN56-induced ferroptosis through robust antioxidant mechanisms, alleviates models of hepatorenal injury, and shows significant potential in preventing a spectrum of ferroptosis-related diseases.
Targets&IC50	Ferroptosis:40.49 nM
In vivo	Methods: Ferroptosis-IN-8 (10 mg/kg, intraperitoneal injection) was used to treat the acetaminophen-induced acute liver injury mouse model and its therapeutic effect was observed. Results: Ferroptosis-IN-8 can reduce the increase of plasma ALT and AST in mice and reduce the liver injury response caused by acetaminophen. [1]
Synonyms	Ferroptosis IN8

Chemical Properties

Molecular Weight	285.3
Formula	C₁₅H₁₅N₃O₃
Cas No.	3056016-82-8
Smiles	O=C(NN=CC1=CC=C(OC)C=C1)C=2C=CC=C(O)C2N
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (140.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5051 mL	17.5254 mL	35.0508 mL	175.2541 mL
5 mM	0.7010 mL	3.5051 mL	7.0102 mL	35.0508 mL
10 mM	0.3505 mL	1.7525 mL	3.5051 mL	17.5254 mL
20 mM	0.1753 mL	0.8763 mL	1.7525 mL	8.7627 mL
50 mM	0.0701 mL	0.3505 mL	0.7010 mL	3.5051 mL
100 mM	0.0351 mL	0.1753 mL	0.3505 mL	1.7525 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc