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Ferroptosis-IN-8

🥰Excellent
Catalog No. T206031Cas No. 3056016-82-8
Alias Ferroptosis IN8

Ferroptosis-IN-8 (Compound B4) is a potent and specific small molecule inhibitor of ferroptosis, demonstrating a half-maximal inhibitory concentration (IC50) of 40.49 nM. it suppresses RSL3- or FIN56-induced ferroptosis through robust antioxidant mechanisms, alleviates models of hepatorenal injury, and shows significant potential in preventing a spectrum of ferroptosis-related diseases.

Ferroptosis-IN-8

Ferroptosis-IN-8

🥰Excellent
Purity: 99.831%
Catalog No. T206031Alias Ferroptosis IN8Cas No. 3056016-82-8
Ferroptosis-IN-8 (Compound B4) is a potent and specific small molecule inhibitor of ferroptosis, demonstrating a half-maximal inhibitory concentration (IC50) of 40.49 nM. it suppresses RSL3- or FIN56-induced ferroptosis through robust antioxidant mechanisms, alleviates models of hepatorenal injury, and shows significant potential in preventing a spectrum of ferroptosis-related diseases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$195-In Stock
5 mg$483-In Stock
10 mg$691-In Stock
25 mg$1,080-In Stock
50 mg$1,490-In Stock
100 mg$1,960-In Stock
200 mg$2,680-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.831%
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Product Introduction

Bioactivity
Description
Ferroptosis-IN-8 (Compound B4) is a potent and specific small molecule inhibitor of ferroptosis, demonstrating a half-maximal inhibitory concentration (IC50) of 40.49 nM. it suppresses RSL3- or FIN56-induced ferroptosis through robust antioxidant mechanisms, alleviates models of hepatorenal injury, and shows significant potential in preventing a spectrum of ferroptosis-related diseases.
Targets&IC50
Ferroptosis:40.49 nM
In vivo
Methods: Ferroptosis-IN-8 (10 mg/kg, intraperitoneal injection) was used to treat the acetaminophen-induced acute liver injury mouse model and its therapeutic effect was observed.
Results: Ferroptosis-IN-8 can reduce the increase of plasma ALT and AST in mice and reduce the liver injury response caused by acetaminophen. [1]
SynonymsFerroptosis IN8
Chemical Properties
Molecular Weight285.3
FormulaC15H15N3O3
Cas No.3056016-82-8
SmilesO=C(NN=CC1=CC=C(OC)C=C1)C=2C=CC=C(O)C2N
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (140.2 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5051 mL17.5254 mL35.0508 mL175.2541 mL
5 mM0.7010 mL3.5051 mL7.0102 mL35.0508 mL
10 mM0.3505 mL1.7525 mL3.5051 mL17.5254 mL
20 mM0.1753 mL0.8763 mL1.7525 mL8.7627 mL
50 mM0.0701 mL0.3505 mL0.7010 mL3.5051 mL
100 mM0.0351 mL0.1753 mL0.3505 mL1.7525 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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