Acetyl-CoA Carboxylase

Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)

Moiramide B is a potent acetyl coenzyme A carboxylase (ACC) inhibitor (IC50:6 nM) with antimicrobial activity, strongly inhibiting Gram-positive bacteria but weakly inhibiting Gram-negative bacteria.

PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively

ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

TOFA (MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).

Quizalofop, a chlorophenoxy and phenoxy herbicide, selectively controls grasses via acetyl-CoA-carboxylase inhibition. While widely used in agriculture, Quizalofop has been associated with developmental and cardiac toxicity in zebrafish embryos.

Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). It has been used in trials studying the treatment of Acne Vulgaris.

PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.

Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells).

CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.

CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.

(±)-Haloxyfop (Haloxyfop Acid) is a herbicide.

Clodinafop-propargyl is a post-emergence herbicide belonging to the propionic acid arylphenoxy (AOPP) class, inhibiting acetyl-CoA carboxylase (ACCase), and is used for annual grass weeds.

Quizalofop-p-ethyl ((R)-Quizalofop ethyl) is a selective post-emergent herbicide for use on annual and perennial weeds, acting as an acetyl-CoA carboxylase (ACCase) inhibitor leading to weed death.

Quizalofop-ethyl (NC 302) is a aryloxyphenoxypropionate herbicide used for post-emergence control of annual and perennial grass weeds within broadleaf crops such as soybeans, cotton, and peanuts, and its herbicidal activity is mediated through the potent inhibition of the acetyl-CoA carboxylase (ACCase) enzyme.

Acetyl-CoA Carboxylase-IN-1 (ACC-IN-1) is an efficient inhibitor of acetyl-CoA carboxylase (ACC), with antibacterial activity, and can be applied in the study of metabolic diseases.

Tralkoxydim (Tralkoxydime) is an alkyl ketone herbicide. Tralkoxydim works as an ACCase inhibitor.

AMPK activator16 (compound 6) functions as an AMP-activated protein kinase (AMPK) inhibitor. It interacts effectively with crucial AMPK residues, significantly activating the enzyme. In N2a cells, AMPK activator16 enhances the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) and phosphorylated raptor (p-raptor).

Propaquizafop, a phenoxyisopropionic acid derivative, is used as a herbicide.

A-908292 is a highly potent and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), displaying an impressive IC50 of 38 nM. This compound serves as a valuable tool in the investigation of fatty acid metabolism [1].

S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2].

(Rac)-Spirotetramat-enol (Compound 8) serves as a ligand for target proteins, utilized in the synthesis of PROTAC ACC degrader.

Quizalofop-P, a selective herbicide, is absorbed by weed stems and leaves before translocating both upward and downward within the plant, concentrating in apical and intercalary meristems. It inhibits fatty acid synthesis at the cellular level, leading to weed necrosis, and exhibits high selectivity between grass weeds and dicotyledonous crops [1].