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TargetMol | Tags Metabolism
ANGPTL
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Acetyl-CoA Carboxylase

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT).

Firsocostat
T71841434635-54-7
Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)
  • $88
In Stock
Size
QTY
TargetMol | Citations Cited
Moiramide B
T73054155233-31-1In house
Moiramide B is a potent acetyl coenzyme A carboxylase (ACC) inhibitor (IC50:6 nM) with antimicrobial activity, strongly inhibiting Gram-positive bacteria but weakly inhibiting Gram-negative bacteria.
  • $748 TargetMol
In Stock
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PF-05175157
T71631301214-47-0
PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively
  • $61
In Stock
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ND-646
TQ02431434639-57-2
ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.
  • $77
In Stock
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TargetMol | Inhibitor Sale
CP-640186
T1889591778-68-6
CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.
  • $32
In Stock
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TOFA
T398854857-86-2
TOFA (MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).
  • $30
In Stock
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TargetMol | Citations Cited
Quizalofop
T1995976578-12-6
Quizalofop, a chlorophenoxy and phenoxy herbicide, selectively controls grasses via acetyl-CoA-carboxylase inhibition. While widely used in agriculture, Quizalofop has been associated with developmental and cardiac toxicity in zebrafish embryos.
  • $50
In Stock
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Olumacostat Glasaretil
T35101261491-89-7
Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). It has been used in trials studying the treatment of Acne Vulgaris.
  • $44
In Stock
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PF-05221304
T92091370448-25-1
PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.
  • $86
In Stock
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CMS-121
T149911353224-53-9
CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.
  • $37
In Stock
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CP-640186 hydrochloride
T3622591778-70-0
CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.
  • $31
In Stock
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Haloxyfop
T504669806-34-4
(±)-Haloxyfop (Haloxyfop Acid) is a herbicide.
  • $42
In Stock
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Clodinafop-propargyl
T38451105512-06-9
Clodinafop-propargyl is a post-emergence herbicide belonging to the propionic acid arylphenoxy (AOPP) class, inhibiting acetyl-CoA carboxylase (ACCase), and is used for annual grass weeds.
  • $30
In Stock
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Quizalofop-p-ethyl
T19537100646-51-3
Quizalofop-p-ethyl ((R)-Quizalofop ethyl) is a selective post-emergent herbicide for use on annual and perennial weeds, acting as an acetyl-CoA carboxylase (ACCase) inhibitor leading to weed death.
  • $36
In Stock
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Quizalofop-ethyl
T1996476578-14-8
Quizalofop-ethyl (NC 302) is a aryloxyphenoxypropionate herbicide used for post-emergence control of annual and perennial grass weeds within broadleaf crops such as soybeans, cotton, and peanuts, and its herbicidal activity is mediated through the potent inhibition of the acetyl-CoA carboxylase (ACCase) enzyme.
  • $39
In Stock
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Acetyl-CoA Carboxylase-IN-1
T72180179343-23-8
Acetyl-CoA Carboxylase-IN-1 (ACC-IN-1) is an efficient inhibitor of acetyl-CoA carboxylase (ACC), with antibacterial activity, and can be applied in the study of metabolic diseases.
  • $30
In Stock
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Tralkoxydim
T1998287820-88-0
Tralkoxydim (Tralkoxydime) is an alkyl ketone herbicide. Tralkoxydim works as an ACCase inhibitor.
  • $50
4-6 weeks
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AMPK activator 16
T2052022252336-04-0
AMPK activator16 (compound 6) functions as an AMP-activated protein kinase (AMPK) inhibitor. It interacts effectively with crucial AMPK residues, significantly activating the enzyme. In N2a cells, AMPK activator16 enhances the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) and phosphorylated raptor (p-raptor).
  • Inquiry Price
10-14 weeks
Size
QTY
Propaquizafop
T20696111479-05-1
Propaquizafop, a phenoxyisopropionic acid derivative, is used as a herbicide.
  • $1,520
6-8 weeks
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QTY
A-908292
T61341903886-95-3
A-908292 is a highly potent and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), displaying an impressive IC50 of 38 nM. This compound serves as a valuable tool in the investigation of fatty acid metabolism [1].
  • $238
5 days
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S-2E
T61430155730-92-0
S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2].
  • $1,520
8-10 weeks
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QTY
Quizalofop-P
T8131994051-08-8
Quizalofop-P, a selective herbicide, is absorbed by weed stems and leaves before translocating both upward and downward within the plant, concentrating in apical and intercalary meristems. It inhibits fatty acid synthesis at the cellular level, leading to weed necrosis, and exhibits high selectivity between grass weeds and dicotyledonous crops [1].
  • Inquiry Price
8-10 weeks
Size
QTY
MK-4074
T120621039758-22-9
MK-4074 is a liver-specific acetyl-CoA carboxylase (ACC1 and ACC2) inhibitor with an IC50 of 3 nM.
  • $3,320
3-6 months
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hacc2-in-1
T62418192323-14-1
hACC2-IN-1 is a potent inhibitor of acetyl coenzyme A carboxylase 2 (ACC2), exhibiting an IC50 of 2.5 μM for hACC2, and holds potential for obesity research.
  • $1,520
6-8 weeks
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