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Thalidomide-Piperazine-Piperidine hydrochloride
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Catalog No. T40231Cas No. 2599846-44-1
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized compound serving as an E3 ligase ligand-linker conjugate, combining the cereblon ligand derived from Thalidomide with a linker commonly used in PROTAC technology.
Thalidomide-Piperazine-Piperidine hydrochloride
😃Good
Catalog No. T40231Cas No. 2599846-44-1
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized compound serving as an E3 ligase ligand-linker conjugate, combining the cereblon ligand derived from Thalidomide with a linker commonly used in PROTAC technology.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | Inquiry | Backorder | Backorder | |
| 500 mg | Inquiry | Backorder | Backorder |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized compound serving as an E3 ligase ligand-linker conjugate, combining the cereblon ligand derived from Thalidomide with a linker commonly used in PROTAC technology. |
| In vitro | PROTACs are composed of two distinct ligands joined by a linker; one ligand targets an E3 ubiquitin ligase while the other targets the protein of interest. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
| Molecular Weight | 461.95 |
| Formula | C22H28ClN5O4 |
| Cas No. | 2599846-44-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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