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SC-57461A

Name: SC-57461A
Brand: TargetMol
SKU: T21696
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21696Cas No. 423169-68-0

SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.

SC-57461A

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Purity: 99.91%

Catalog No. T21696Cas No. 423169-68-0

SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$44	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$147	In Stock	In Stock
50 mg	$239	In Stock	In Stock
100 mg	$348	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.

In vitro

57461A is a potent competitive inhibitor of recombinant human LTA(4) hydrolase when either LTA(4) (IC(50) = 2.5 nM, K(i) = 23 nM) or peptide substrates (IC(50) = 27 nM) are used.?In human whole blood, the IC(50) for calcium ionophore-induced LTB(4) production was 49 nM, indicative of good cell penetration.?Whole blood production of the cyclooxygenase metabolite thromboxane B(2) was not affected.?SC-57461A was also active in several other species, including mouse, rat, dog, and rhesus monkey.?The data indicate that SC-57461A is a potent and selective inhibitor of LTA(4) hydrolase[2].

Chemical Properties

Molecular Weight	363.9
Formula	C₂₀H₂₆ClNO₃
Cas No.	423169-68-0
Smiles	Cl.CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(O)=O
Relative Density.	1.115g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (151.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7480 mL	13.7400 mL	27.4801 mL	137.4004 mL
5 mM	0.5496 mL	2.7480 mL	5.4960 mL	27.4801 mL
10 mM	0.2748 mL	1.3740 mL	2.7480 mL	13.7400 mL
20 mM	0.1374 mL	0.6870 mL	1.3740 mL	6.8700 mL
50 mM	0.0550 mL	0.2748 mL	0.5496 mL	2.7480 mL
100 mM	0.0275 mL	0.1374 mL	0.2748 mL	1.3740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc