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SC-57461A

Name: SC-57461A
Brand: TargetMol
SKU: T21696
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21696Cas No. 423169-68-0

SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.

SC-57461A

🥰Excellent

Purity: 99.91%

Catalog No. T21696Cas No. 423169-68-0

SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$58	In Stock
10 mg	$93	In Stock
25 mg	$188	In Stock
50 mg	$296	In Stock
100 mg	$433	In Stock
200 mg	$616	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.

In vitro

57461A is a potent competitive inhibitor of recombinant human LTA(4) hydrolase when either LTA(4) (IC(50) = 2.5 nM, K(i) = 23 nM) or peptide substrates (IC(50) = 27 nM) are used.?In human whole blood, the IC(50) for calcium ionophore-induced LTB(4) production was 49 nM, indicative of good cell penetration.?Whole blood production of the cyclooxygenase metabolite thromboxane B(2) was not affected.?SC-57461A was also active in several other species, including mouse, rat, dog, and rhesus monkey.?The data indicate that SC-57461A is a potent and selective inhibitor of LTA(4) hydrolase[2].

Chemical Properties

Molecular Weight	363.9
Formula	C₂₀H₂₆ClNO₃
Cas No.	423169-68-0
Smiles	Cl.CN(CCCOc1ccc(Cc2ccccc2)cc1)CCC(O)=O
Relative Density.	1.115g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (151.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7480 mL	13.7400 mL	27.4801 mL	137.4004 mL
5 mM	0.5496 mL	2.7480 mL	5.4960 mL	27.4801 mL
10 mM	0.2748 mL	1.3740 mL	2.7480 mL	13.7400 mL
20 mM	0.1374 mL	0.6870 mL	1.3740 mL	6.8700 mL
50 mM	0.0550 mL	0.2748 mL	0.5496 mL	2.7480 mL
100 mM	0.0275 mL	0.1374 mL	0.2748 mL	1.3740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc