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Anti-Nicastrin Antibody-FITC (4B647)
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Catalog No. TMAY-01719F
Alias nicastrin, Nct, NCSTN, mKIAA0253, Kiaa0253, D1Dau13e, Aph2, AA727311, 9430068N19Rik
Anti-Nicastrin Antibody-FITC (4B647) is a FITC-conjugated Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody-FITC (4B647) can be used in FCM.
Anti-Nicastrin Antibody-FITC (4B647)
Anti-Nicastrin Antibody-FITC (4B647)
😃Good
Catalog No. TMAY-01719FAlias nicastrin, Nct, NCSTN, mKIAA0253, Kiaa0253, D1Dau13e, Aph2, AA727311, 9430068N19Rik
Anti-Nicastrin Antibody-FITC (4B647) is a FITC-conjugated Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody-FITC (4B647) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 T | $105 | 7-10 days | |
| 100 T | $210 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: FCM Reactivity: Human |
| Alias | nicastrin, Nct, NCSTN, mKIAA0253, Kiaa0253, D1Dau13e, Aph2, AA727311, 9430068N19Rik |
| Ig Type | Rabbit IgG |
| Clone | 4B647 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of NCSTN on HepG2 cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Nicastrin / NCSTN (rh Nicastrin / NCSTN; TMPY-01297; NP_056146.1; Met1-Glu669) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing pieces of evidence have shown that Nicastrin/NCSTN plays a crucial role in gamma-cleavage of the amyloid precursor protein (APP). The glycoprotein Nicastrin is an essential component of the gamma-secretase complex, a high molecular weight complex that also contains the presenilin proteins, Aph-1 and Pen-2. The gamma-secretase complex is not only involved in APP processing but also in the processing of an increasing number of another type I integral membrane proteins. As the largest subunit of the gamma-secretase complex, Nicastrin plays a crucial role in its activation. Inhibition of NCSTN demonstrated an altered gamma-cleavage activity, suggesting its potential implication in developing Alzheimer's disease (AD). Besides, Nicastrin can function to maintain epithelial to mesenchymal transition during breast cancer progression. Anti-nicastrin polyclonal and monoclonal antibodies were able to decrease notch1 and vimentin expression and reduced the invasive capacity of breast cancer cells in vitro. |
| Conjucates | FITC |
| Others Formats | Unconjugated/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Protein: Human Nicastrin / NCSTN protein (TMPY-01297) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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