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Adecatumumab

Catalog No. T77747 CAS 503605-66-1

Synonyms: MT 201

Adecatumumab (MT201) is a whole-person IgG1 monoclonal antibody to human EpCAM. Adecatumumab has potential anticancer activity and can be used to study breast cancer.

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Adecatumumab

Adecatumumab, CAS 503605-66-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 289.00
5 mg	In stock	$ 788.00
10 mg	In stock	$ 1,230.00
25 mg	In stock	$ 1,850.00
50 mg	In stock	$ 2,490.00
100 mg	In stock	$ 3,360.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Adecatumumab (MT201) is a whole-person IgG1 monoclonal antibody to human EpCAM. Adecatumumab has potential anticancer activity and can be used to study breast cancer.
In vitro	Among human Adecatumumab and murine Adecatumumab, there are diverse kinetic binding activities observed in B16/EpCAM 3E3 cells when treated with Adecatumumab (4 μM; 18 h)[2]. Adecatumumab (0.1 ng/mL-0.1 mg/mL; 4 h) exhibits dose-dependent activity in Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in natural killer (NK) cells[2].
In vivo	In the B16/EpCAM xenograft tumor model in mice, both human adecatumumab and mu-adecatumumab (300 μg/mouse; i.v. bolus injection; 3 times per week) demonstrate inhibition of tumor growth[2]. Both human adecatumumab and mu-adecatumumab (300 μg/mouse; i.v. bolus injection; single dose) display a bi-exponential curve progression of serum concentration, characterized by an early distribution phase between 0 and 10 h and a terminal elimination phase[2].

Synonyms	MT 201
Molecular Weight	N/A
CAS No.	503605-66-1

Storage

store at low temperature

store at -80°C

References and Literature

1. Kurtz JE, et al. Adecatumumab: an anti-EpCAM monoclonal antibody, from the bench to the bedside. Expert Opin Biol Ther. 2010 Jun;10(6):951-8. 2. Lutterbuese P, et al. Exchanging human Fcgamma1 with murine Fcgamma2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model. Cancer Immunol Immunother. 2007 Apr;56(4):459-68.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Adecatumumab 503605-66-1 Others MT 201 MT201 MT-201 inhibitor inhibit

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