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5-HT6R/FAAH modulator 1
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Catalog No. T213090 Copy Product Info
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5-HT6R/FAAH modulator 1 is a selective ligand for the serotonin 5-HT6 receptor and an inhibitor of the fatty acid amide hydrolase (FAAH). It exhibits a pKi of 6.33 for 5-HT6 and a pIC50 of 6.33 for FAAH. This compound also shows mild inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with a pIC50 of 5.12. Additionally, it can inhibit apoptosis and reduce reactive oxygen species (ROS) levels. 5-HT6R/FAAH modulator 1 is applicable in the study of neurological disorders such as Alzheimer's disease (AD).
5-HT6R/FAAH modulator 1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | 5-HT6R/FAAH modulator 1 is a selective ligand for the serotonin 5-HT6 receptor and an inhibitor of the fatty acid amide hydrolase (FAAH). It exhibits a pKi of 6.33 for 5-HT6 and a pIC50 of 6.33 for FAAH. This compound also shows mild inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with a pIC50 of 5.12. Additionally, it can inhibit apoptosis and reduce reactive oxygen species (ROS) levels. 5-HT6R/FAAH modulator 1 is applicable in the study of neurological disorders such as Alzheimer's disease (AD). |
| Targets & IC50 | 5-HT6 Receptor:6.33 (pKi) |
| In vitro | 5-HT6R/FAAH modulator 1 (Compound 23) at concentrations ranging from 0.3 to 30 μM reduces the growth of HepG2 and SH-SY5Y cells over a period of 72 hours. Applied at 10 μM for 17 hours, it enhances the survival rate of HT-22 cells treated with Aβ1-42, inhibits apoptosis, and decreases reactive oxygen species levels. Additionally, at 0.03 to 0.15 μM, it exhibits significant antioxidant activity. |
| In vivo | Compound 23, a 5-HT6R/FAAH modulator, administered via intraperitoneal injection at doses of 0.3-1 mg/kg, can reverse memory impairment in rat models induced by MK-801. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Related Tags: 5-HT6R/FAAH modulator 1 in vivo | 5-HT6R/FAAH modulator 1 in vitro
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