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PPADS tetrasodium

Name: PPADS tetrasodium
Brand: TargetMol
SKU: T16564
Rating: 4.5 (1 reviews)

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Catalog No. T16564Cas No. 192575-19-2

PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma inhibits P2X1, P2X-2, P2X-3, and P2X- 5. 5.

PPADS tetrasodium

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Purity: 95%

Catalog No. T16564Cas No. 192575-19-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$44	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:95%

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Product Introduction

Bioactivity

Description	PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma inhibits P2X1, P2X-2, P2X-3, and P2X- 5. 5.
Targets&IC50	P2X receptors:1-3 μM, P2X4 (human):30 μM
In vitro	In a time- and concentration-dependent manner, PPADS tetrasodiuma (1-30 μM; 10-50 minutes) inhibits Na+/Ca2+ exchanger reverse mode (NCXREV)[2]. PPADS tetrasodiuma is effective at other native and recombinant P2XRs. Sensitivity to PPADS tetrasodiuma at human P2XRs depends on the subtype and is highest at the hP2X1, -2, -3, -5, and -7Rs with an IC50 of ~1-3 μM and ~30 μM for the hP2X4R[3].
In vivo	In mesangial proliferative glomerulonephritis, PPADS tetrasodiuma (15-60 mg/100g body weight (BW); i.p.; every 12 hours for 8 days) inhibits the proliferation of glomerular mesangial cells (MC) without altering the proliferation of non-MC in vivo[4].

Chemical Properties

Molecular Weight	599.3
Formula	C₁₄H₁₀N₃Na₄O₁₂PS₂
Cas No.	192575-19-2
Smiles	O=CC1=C(C(C)=NC(N=NC2=CC=C(S(=O)([O-])=O)C=C2S(=O)([O-])=O)=C1COP([O-])([O-])=O)O.[Na+].[Na+].[Na+].[Na+]
Relative Density.	no data available
Color	Red
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (66.74 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.6686 mL	8.3431 mL	16.6861 mL	83.4307 mL
5 mM	0.3337 mL	1.6686 mL	3.3372 mL	16.6861 mL
10 mM	0.1669 mL	0.8343 mL	1.6686 mL	8.3431 mL
20 mM	0.0834 mL	0.4172 mL	0.8343 mL	4.1715 mL
50 mM	0.0334 mL	0.1669 mL	0.3337 mL	1.6686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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